GEM and CACNB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GEM	CACNB3
Description		GTP binding protein overexpressed in skeletal muscle	calcium voltage-gated channel auxiliary subunit beta 3
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Spindle Midzone Mitotic Spindle	Cytoplasm Cytosol Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Chromosome Alignment	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport T Cell Receptor Signaling Pathway Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		NPAS4 regulates expression of target genes	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BLOC1S2 BLZF1 BMP1 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 DRC4 ECSIT EFHC2 EXOSC8 FSAF1 GADD45GIP1 GMIP GOLGA2 GOLGA6L9 GOPC GPRASP3 HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9	11 interacting genes: CACNA1B CACNA1C CEP76 CIMIP1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIC2 SYT1
Entrez ID		2669	784
HPRD ID		11553	11879
Ensembl ID		ENSG00000164949	ENSG00000167535
Uniprot IDs		P55040	P54284
PDB IDs		2CJW 2G3Y 2HT6	7MIX 7MIY 7UHF 7UHG 8E59 8E5A 8E5B 8EPL 8FHS 8WE6 8WE7 8WE8 8WE9 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Keratin Filament Intermediate Filament Cytoskeleton Intermediate Filament Organization Microtubule Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Cytoskeleton Organization Zinc Ion Binding Organelle Organization TORC1 Complex Assembly Centrosome Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Microtubule-based Process Supramolecular Fiber Organization Ubiquitin Protein Ligase Activity Regulation Of Viral Transcription Protein Localization To Cytoskeleton	Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transmembrane Import Into Cytosol High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Neurotransmitter Secretion Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Voltage-gated Calcium Channel Activity Calcium Ion Import Calcium Ion Transmembrane Transport Calmodulin Binding Regulation Of Calcium Ion-dependent Exocytosis Metal Ion Transport Calcium Ion Transport Positive Regulation Of Regulated Secretory Pathway Regulation Of Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell Communication Monoatomic Cation Transport Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Calcium Channel Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of Exocytosis Inorganic Cation Import Across Plasma Membrane Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Positive Regulation Of Chromatin Organization Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Sclerotome Development Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Syntaxin-3 Binding Cytoplasmic Vesicle Lumen Monoatomic Ion Transport X Chromosome
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