XAB2 and PPIE

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology), HPRD (two hybrid)

		XAB2	PPIE
Name		XPA binding protein 2	peptidylprolyl isomerase E
Structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Poly(A) Binding Cyclosporin A Binding Isomerase Activity
	Biological Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Blastocyst Development DNA Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription RNA Processing MRNA Processing DNA Damage Response RNA Splicing Cerebral Cortex Development	MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neutrophil degranulation mRNA Splicing - Major Pathway
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 )
Interacting Genes		18 interacting genes: CACHD1 DHX16 DSCR9 ERCC6 ERCC8 GLIS2 ILF3 MIR106B MIR34B MIRLET7E MIRLET7G MIRLET7I POLR2A PPIE RNF10 SMAD9 SUMO2 XPA	11 interacting genes: GTSE1 KMT2A PCM1 PHYHIP PRC1 PRPF6 SLU7 SUMO2 TRIM55 TRIM63 XAB2
Entrez ID		56949	10450
HPRD ID		18306	03893
Ensembl ID		ENSG00000076924	ENSG00000084072
Uniprot IDs		Q9HCS7	E9PK21 Q9UNP9
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	1ZMF 2CQB 2KU7 2KYX 2R99 3LPY 3MDF 3UCH 5MQF 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 7A5P 7ABI 7W59 7W5A 7W5B 7ZEV 7ZEW 7ZEX 7ZEY 7ZEZ 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD
GO Terms Enriched among Interactors		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulatory NcRNA-mediated Gene Silencing RISC Complex Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Transcription-coupled Nucleotide-excision Repair MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Response To X-ray Positive Regulation Of MRNA Metabolic Process Response To UV Base-excision Repair Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Gene Expression Regulation Of Transcription-coupled Nucleotide-excision Repair Site Of DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translation Nucleotide-excision Repair, DNA Damage Recognition Regulation Of MRNA Stability MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing, Via Transesterification Reactions Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	Catalytic Step 2 Spliceosome Microtubule MRNA Splicing, Via Spliceosome Spliceosomal Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Microtubule Cytoskeleton Second Spliceosomal Transesterification Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Protein-containing Complex Localization To Centriolar Satellite Mitotic Spindle Elongation Generation Of Catalytic Spliceosome For First Transesterification Step Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Nucleoplasm