XAB2 and DHX16

Number of citations: 0 (PubMedID 22365833)
Data Source: BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		XAB2	DHX16
Name		XPA binding protein 2	DEAH-box helicase 16
Structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm U2-type Precatalytic Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Blastocyst Development DNA Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription RNA Processing MRNA Processing DNA Damage Response RNA Splicing Cerebral Cortex Development	MRNA Splicing, Via Spliceosome Immune System Process MRNA Processing RNA Splicing Innate Immune Response Antiviral Innate Immune Response
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		18 interacting genes: CACHD1 DHX16 DSCR9 ERCC6 ERCC8 GLIS2 ILF3 MIR106B MIR34B MIRLET7E MIRLET7G MIRLET7I POLR2A PPIE RNF10 SMAD9 SUMO2 XPA	13 interacting genes: APP APPBP2 COIL CSNK2A1 ESS2 HOMEZ MEGF10 MYO19 RIGI RNF10 SNRNP27 TFIP11 XAB2
Entrez ID		56949	8449
HPRD ID		18306	04555
Ensembl ID		ENSG00000076924	ENSG00000204560
Uniprot IDs		Q9HCS7	A0A1U9X7L7 B4DZ28 O60231 Q5SQH4 Q5SQH5
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	5Z56 5Z57 5Z58 6FF7 7DVQ 7QTT 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V
GO Terms Enriched among Interactors		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulatory NcRNA-mediated Gene Silencing RISC Complex Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Transcription-coupled Nucleotide-excision Repair MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Response To X-ray Positive Regulation Of MRNA Metabolic Process Response To UV Base-excision Repair Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Gene Expression Regulation Of Transcription-coupled Nucleotide-excision Repair Site Of DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translation Nucleotide-excision Repair, DNA Damage Recognition Regulation Of MRNA Stability MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing, Via Transesterification Reactions Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	MRNA Metabolic Process MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome RNA Splicing MRNA Processing RNA Metabolic Process Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Mitochondrion Migration Along Actin Filament