DDB2 and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 32789493)
41

Data Source:
BioGRID (enzymatic study)

		DDB2	SIRT6
Description		damage specific DNA binding protein 2	sirtuin 6
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cell Junction Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Endoplasmic Reticulum Site Of Double-strand Break Site Of DNA Damage Chromosome, Subtelomeric Region
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	DNA Binding Chromatin Binding Damaged DNA Binding Transcription Corepressor Activity RNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Deacetylase Activity, NAD-dependent Enzyme Regulator Activity Chromatin DNA Binding Nucleosome Binding Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism NAD-dependent Protein Lysine Deacetylase Activity Histone Deacetylase Regulator Activity Protein Homodimerization Activity Metal Ion Binding Histone H3K9 Deacetylase Activity, NAD-dependent NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD+-protein-arginine ADP-ribosyltransferase Activity DNA Damage Sensor Activity Histone H3K56 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein-lysine ADP-ribosyltransferase Activity TORC2 Complex Binding NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair DNA Damage Response Response To UV Protein Ubiquitination Cellular Response To UV Protein Autoubiquitination UV-damage Excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Base-excision Repair Double-strand Break Repair Chromatin Organization Chromatin Remodeling Protein Deacetylation Protein Import Into Nucleus Inflammatory Response DNA Damage Response Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Response To UV Transposable Element Silencing Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Lipid Metabolic Process Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Protein Destabilization Positive Regulation Of Insulin Secretion Positive Regulation Of Telomere Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Transcription Elongation By RNA Polymerase II Ketone Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Glucose Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Regulation Of Protein Secretion Regulation Of Lipid Catabolic Process Protein Delipidation Cardiac Muscle Cell Differentiation Protein Poly-ADP-ribosylation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling Transcription Pausing By RNA Polymerase II Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Chondrocyte Proliferation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Protein Localization To Site Of Double-strand Break Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	18 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 DDB2 ELF5 FAF1 H3C1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A VIM
Entrez ID		1643	51548
HPRD ID		02886	12093
Ensembl ID		ENSG00000134574	ENSG00000077463
Uniprot IDs		Q92466	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY 6QCD 6QCE 6QCH 6QCJ 6XUY 6XV1 6XV6 6XVG 6ZU4 7CL0 7CL1 8AK5 8AK6 8AK7 8AK8 8AK9 8AKA 8AKB 8AKC 8AKD 8AKE 8AKF 8AKG 8BL0 8BL1 8CNM 8CNO 8F86 8G57 8I2B 8OF4 9G7H
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding UV-damage Excision Repair Response To Radiation Nucleoplasm DNA Metabolic Process DNA Repair DNA Damage Response Nucleus Response To UV DNA Binding Cellular Response To Radiation Cellular Response To UV Macromolecule Metabolic Process Cellular Response To Light Stimulus Nucleic Acid Metabolic Process Chromatin Remodeling Rhythmic Process Cul4A-RING E3 Ubiquitin Ligase Complex Chromatin Binding Response To Light Stimulus Chromatin Organization Cellular Response To Stress Regulation Of Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Protein Modification Process Cul4-RING E3 Ubiquitin Ligase Complex Nuclear Chromosome Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Sensor Activity Chromatin Positive Regulation Of Morphogenesis Of An Epithelium Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Morphogenesis Of A Branching Structure Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Regulation Of Macromolecule Metabolic Process Chromosome Organization Regulation Of Blood Vessel Branching Bubble DNA Binding Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway Embryonic Cleavage	Nucleus Nucleoplasm Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Protein Metabolic Process DNA Damage Response DNA Repair Checkpoint Clamp Complex Positive Regulation Of Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Meiotic Cell Cycle Checkpoint Signaling Positive Regulation Of Protein Modification Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Reproductive Process Damaged DNA Binding DNA N-glycosylase Activity Protein Modification By Small Protein Conjugation Protein Autoubiquitination Positive Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Ubiquitin-protein Transferase Activity Base-excision Repair, AP Site Formation Regulation Of TORC1 Signaling Post-translational Protein Modification Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Regulation Of DNA Replication Regulation Of Nucleobase-containing Compound Metabolic Process DNA Modification Regulation Of Protein Polyubiquitination Negative Regulation Of Cell Cycle Response To Stress
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