DDB2 and NTMT1

Number of citations of the paper that reports this interaction (PubMedID 24753253)
39

Data Source:
BioGRID (enzymatic study)

		DDB2	NTMT1
Description		damage specific DNA binding protein 2	N-terminal Xaa-Pro-Lys N-methyltransferase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cell Junction Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity N-terminal Protein N-methyltransferase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair DNA Damage Response Response To UV Protein Ubiquitination Cellular Response To UV Protein Autoubiquitination UV-damage Excision Repair	Chromatin Remodeling Spindle Organization Chromosome Segregation N-terminal Peptidyl-glycine Methylation N-terminal Peptidyl-proline Dimethylation Methylation N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	7 interacting genes: APP DDB2 DIS3 GLYR1 HNRNPD IKBKG RCC1
Entrez ID		1643	28989
HPRD ID		02886	10628
Ensembl ID		ENSG00000134574	ENSG00000148335
Uniprot IDs		Q92466	Q9BV86 S4R338
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	2EX4 5CVD 5CVE 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 6DTN 6KDQ 6PVA 6PVB 6WH8 6WJ7 7K3D 7SS1 7U1M
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding UV-damage Excision Repair Response To Radiation Nucleoplasm DNA Metabolic Process DNA Repair DNA Damage Response Nucleus Response To UV DNA Binding Cellular Response To Radiation Cellular Response To UV Macromolecule Metabolic Process Cellular Response To Light Stimulus Nucleic Acid Metabolic Process Chromatin Remodeling Rhythmic Process Cul4A-RING E3 Ubiquitin Ligase Complex Chromatin Binding Response To Light Stimulus Chromatin Organization Cellular Response To Stress Regulation Of Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Protein Modification Process Cul4-RING E3 Ubiquitin Ligase Complex Nuclear Chromosome Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Sensor Activity Chromatin Positive Regulation Of Morphogenesis Of An Epithelium Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Morphogenesis Of A Branching Structure Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Regulation Of Macromolecule Metabolic Process Chromosome Organization Regulation Of Blood Vessel Branching Bubble DNA Binding Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway Embryonic Cleavage	Positive Regulation Of Catabolic Process Chromatin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Nucleosome Binding Protein-containing Complex Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Heterodimerization Activity Chromatin Hepatocyte Dedifferentiation Cellular Response To Putrescine Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import Nucleoplasm MRNA Destabilization RNA Destabilization Circadian Regulation Of Translation Nuclear MRNA Surveillance Of MRNA 3'-end Processing PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of MRNA Catabolic Process Linear Polyubiquitin Binding Post-transcriptional Regulation Of Gene Expression Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Chromosome
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