DDB2 and USP40

Number of citations of the paper that reports this interaction (PMID 11673459)
52

Data Source:
HPRD (in vivo)

		DDB2	USP40
Gene Name		damage-specific DNA binding protein 2, 48kDa	ubiquitin specific peptidase 40
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity
	Biological Process	Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Response To UV Histone H2A Monoubiquitination Protein Autoubiquitination UV-damage Excision Repair	Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Bilirubin levels ( 21646302) Crohn's disease ( 22412388)
Protein-Protein Interactions		15 interactors: ABL1 CUL4A CUL4B DCLRE1C DDB1 E2F1 HDAC1 HIST2H2AC HIST2H3C NTMT1 TOP1 USP24 USP40 XPA XPC	2 interactors: DDB1 DDB2
Entrez ID		1643	55230
HPRD ID		02886	07166
Ensembl ID		ENSG00000134574	ENSG00000085982
Uniprot IDs		Q92466	Q9NVE5
PDB IDs		3EI4 3I7L 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process DNA Repair Regulation Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Catabolic Process Regulation Of Cell Cycle Cellular Response To Stress Response To UV DNA Catabolic Process Intrinsic Apoptotic Signaling Pathway Response To Radiation Response To Stress UV-damage Excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Histone H2A Monoubiquitination Nucleotide-excision Repair Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Abiotic Stimulus Histone H2A Ubiquitination Response To Light Stimulus Positive Regulation Of Mitotic Cell Cycle Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Cellular Metabolic Process Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone Monoubiquitination Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Aromatic Compound Catabolic Process Negative Regulation Of Cell Cycle Interaction With Symbiont	UV-damage Excision Repair Histone H2A Monoubiquitination Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Histone Ubiquitination Protein Monoubiquitination Cellular Response To UV Nucleotide-excision Repair Cellular Response To Light Stimulus Response To UV DNA Catabolic Process Cellular Response To Radiation Response To Light Stimulus Positive Regulation By Virus Of Viral Protein Levels In Host Cell Histone Modification Response To Radiation Aromatic Compound Catabolic Process Positive Regulation Of Viral Release From Host Cell Protein Ubiquitination DNA Repair Chromatin Modification Protein Modification By Small Protein Conjugation Chromatin Organization Pyrimidine Dimer Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Chromosome Organization DNA Metabolic Process Response To Abiotic Stimulus Interaction With Symbiont Protein Autoubiquitination Cellular Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Process Protein Polyubiquitination Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Wnt Signaling Pathway
Tagcloud ?		adherens bioassays bladder carcinogenic carcinogens chemicals consistently construct discriminate evaluating foundation gadd45a genotoxic genotoxicity globaltest hepg2 implemented industry investigating junction microarrays pam peroxisome perturbation pharmaceutical rrm2b set sets validate
Tagcloud (Difference) ?		adherens bioassays bladder carcinogenic carcinogens chemicals consistently construct discriminate evaluating foundation gadd45a genotoxic genotoxicity globaltest hepg2 implemented industry investigating junction microarrays pam peroxisome perturbation pharmaceutical rrm2b set sets validate
Tagcloud (Intersection) ?