DDB2 and XPC

Number of citations of the paper that reports this interaction (PubMedID 28760956)
45

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vivo)

		DDB2	XPC
Description		damage specific DNA binding protein 2	XPC complex subunit, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cell Junction Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane XPC Complex Site Of DNA Damage
	Molecular Function	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding	Heteroduplex DNA Loop Binding Bubble DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Damage Sensor Activity
	Biological Process	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair DNA Damage Response Response To UV Protein Ubiquitination Cellular Response To UV Protein Autoubiquitination UV-damage Excision Repair	Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair DNA Damage Response Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription UV-damage Excision Repair Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation	SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) High density lipoprotein cholesterol levels ( 33339817) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC	17 interacting genes: BTG3 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMC5 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B
Entrez ID		1643	7508
HPRD ID		02886	02046
Ensembl ID		ENSG00000134574	ENSG00000154767
Uniprot IDs		Q92466	Q01831 X5DRB1
PDB IDs		3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92	2A4J 2GGM 2OBH 2RVB 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding UV-damage Excision Repair Response To Radiation Nucleoplasm DNA Metabolic Process DNA Repair DNA Damage Response Nucleus Response To UV DNA Binding Cellular Response To Radiation Cellular Response To UV Macromolecule Metabolic Process Cellular Response To Light Stimulus Nucleic Acid Metabolic Process Chromatin Remodeling Rhythmic Process Cul4A-RING E3 Ubiquitin Ligase Complex Chromatin Binding Response To Light Stimulus Chromatin Organization Cellular Response To Stress Regulation Of Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Protein Modification Process Cul4-RING E3 Ubiquitin Ligase Complex Nuclear Chromosome Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Sensor Activity Chromatin Positive Regulation Of Morphogenesis Of An Epithelium Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Morphogenesis Of A Branching Structure Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Regulation Of Macromolecule Metabolic Process Chromosome Organization Regulation Of Blood Vessel Branching Bubble DNA Binding Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway Embryonic Cleavage	Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Nucleoplasm Cellular Response To Stress Nucleic Acid Metabolic Process Macromolecule Metabolic Process Proteasome Complex Nucleus Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process XPC Complex Base-excision Repair Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process UV-damage Excision Repair UV Protection Transcription Factor TFIIH Core Complex Transcription-coupled Nucleotide-excision Repair Proteasome Regulatory Particle, Base Subcomplex Transcription Factor TFIIH Holo Complex DNA Replication Factor A Complex Cellular Response To UV Proteasomal Protein Catabolic Process Proteasome Accessory Complex Ubiquitin Binding Proteasome Binding Cellular Response To Light Stimulus Single-stranded DNA Binding PML Body Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Radiation Site Of DNA Damage Response To Radiation Protein-containing Complex Nucleotide-excision Repair Factor 3 Complex
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