DDB1 and HOXD3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		DDB1	HOXD3
Gene Name		damage-specific DNA binding protein 1, 127kDa	homeobox D3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Viral Process Wnt Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell-matrix Adhesion Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Thyroid Gland Development Positive Regulation Of Neuron Differentiation Embryonic Skeletal System Morphogenesis Cartilage Development
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Ovarian cancer ( 20852632)
Protein-Protein Interactions		40 interactors: ABL1 BRAP CDT1 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DTL DYRK2 ERCC8 GPS1 HIST1H1C HIST1H3A HOXD3 IP6K1 LMO4 MAFB MEF2A PIN1 RASSF1 RBX1 SALL2 SIN3A SKP2 STAT1 SUPT3H TP53 UNG USP40 VAMP3 WDTC1 XPA ZNF277	4 interactors: ALX4 DDB1 HMGB1 HOXA1
Entrez ID		1642	3232
HPRD ID		10952	00863
Ensembl ID		ENSG00000167986	ENSG00000128652
Uniprot IDs		Q16531	P31249
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cullin Deneddylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination DNA Repair Protein Deneddylation Heterocycle Metabolic Process Protein Modification By Small Protein Conjugation Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Protein Modification By Small Protein Removal Nitrogen Compound Metabolic Process Response To UV Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Protein Monoubiquitination Immune System Development Cellular Response To Stimulus Metabolic Process Catabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Response To Radiation Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Process Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Protein Metabolic Process Cellular Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching	Optokinetic Behavior Abducens Nerve Formation Negative Regulation Of Apoptotic Cell Clearance Embryonic Skeletal System Morphogenesis DNA Catabolic Process Embryonic Skeletal System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Facial Nucleus Development Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhombomere 4 Development Semicircular Canal Formation Negative Regulation Of DNA-templated Transcription, Initiation Rhombomere 3 Development Rhombomere 5 Development Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Base-excision Repair, DNA Ligation Skeletal System Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death UV-damage Excision Repair Embryonic Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Response To Light Stimulus Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Viral Release From Host Cell Embryonic Neurocranium Morphogenesis Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Outer Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Rhombomere Development Regulation Of Apoptotic Cell Clearance Facial Nerve Structural Organization Pons Development Histone H2A Monoubiquitination Negative Regulation Of Phagocytosis Cellular Nitrogen Compound Metabolic Process Facial Nerve Morphogenesis Response To Radiation Aromatic Compound Catabolic Process DNA Ligation Dendritic Cell Chemotaxis
Tagcloud ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates introduced invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant
Tagcloud (Difference) ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	alphavbeta3 characterizes cooperating cyclin d1a d1b damaged ectopic enhance exploration holds indicates introduced invasive invasiveness makes mcf mediator metastatic modulate notably oncogenic poorly promotes released reveal splice toll variant
Tagcloud (Intersection) ?