DDB1 and CNOT2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		DDB1	CNOT2
Gene Name		damage-specific DNA binding protein 1, 127kDa	CCR4-NOT transcription complex, subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding	RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Corepressor Binding Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Viral Process Wnt Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Maintenance
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		40 interactors: ABL1 BRAP CDT1 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DTL DYRK2 ERCC8 GPS1 HIST1H1C HIST1H3A HOXD3 IP6K1 LMO4 MAFB MEF2A PIN1 RASSF1 RBX1 SALL2 SIN3A SKP2 STAT1 SUPT3H TP53 UNG USP40 VAMP3 WDTC1 XPA ZNF277	7 interactors: CNOT1 CNOT3 CNOT8 DDB1 GPS2 NCOR1 NCOR2
Entrez ID		1642	4848
HPRD ID		10952	05367
Ensembl ID		ENSG00000167986	ENSG00000111596
Uniprot IDs		Q16531	B2RDX7 B3KTL6 Q9NZN8
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cullin Deneddylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination DNA Repair Protein Deneddylation Heterocycle Metabolic Process Protein Modification By Small Protein Conjugation Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Protein Modification By Small Protein Removal Nitrogen Compound Metabolic Process Response To UV Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Protein Monoubiquitination Immune System Development Cellular Response To Stimulus Metabolic Process Catabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Response To Radiation Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Process Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Protein Metabolic Process Cellular Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching	Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process RNA Catabolic Process Regulation Of Stem Cell Maintenance Chromatin Organization RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of JNK Cascade Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Translation Cellular Macromolecule Catabolic Process Posttranscriptional Gene Silencing Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process MRNA Processing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of Gene Expression RNA Processing Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway
Tagcloud ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Difference) ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Intersection) ?