DDB1 and DTL

Number of citations of the paper that reports this interaction (PMID 16964240)
149

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DDB1	DTL
Gene Name		damage-specific DNA binding protein 1, 127kDa	denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Viral Process Wnt Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Translesion Synthesis G2 DNA Damage Checkpoint Regulation Of Cell Cycle
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		40 interactors: ABL1 BRAP CDT1 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DTL DYRK2 ERCC8 GPS1 HIST1H1C HIST1H3A HOXD3 IP6K1 LMO4 MAFB MEF2A PIN1 RASSF1 RBX1 SALL2 SIN3A SKP2 STAT1 SUPT3H TP53 UNG USP40 VAMP3 WDTC1 XPA ZNF277	11 interactors: ATR CDT1 CHEK1 CUL4B DDB1 KAT2A PCNA SETD8 TDG TOB1 UBE2D1
Entrez ID		1642	51514
HPRD ID		10952	17952
Ensembl ID		ENSG00000167986	ENSG00000143476
Uniprot IDs		Q16531	F5GZ90 Q9NZJ0
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cullin Deneddylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination DNA Repair Protein Deneddylation Heterocycle Metabolic Process Protein Modification By Small Protein Conjugation Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Protein Modification By Small Protein Removal Nitrogen Compound Metabolic Process Response To UV Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Protein Monoubiquitination Immune System Development Cellular Response To Stimulus Metabolic Process Catabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Response To Radiation Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Process Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Protein Metabolic Process Cellular Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching	Cellular Response To UV Cellular Response To Light Stimulus Chromosome Organization DNA Metabolic Process DNA Repair Chromatin Modification Response To UV Chromatin Organization Cellular Response To Radiation Histone Modification Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Cell Cycle Process UV-damage Excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA Replication Mitotic Cell Cycle Process Organelle Organization Negative Regulation Of Biosynthetic Process Response To Light Stimulus Mitotic Cell Cycle Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Replicative Senescence Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Histone Monoubiquitination Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Abiotic Stimulus Regulation Of Metabolic Process Histone Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid
Tagcloud (Difference) ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid
Tagcloud (Intersection) ?