DDB1 and WDTC1

Number of citations of the paper that reports this interaction (PMID 16949367)
175

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DDB1	WDTC1
Gene Name		damage-specific DNA binding protein 1, 127kDa	WD and tetratricopeptide repeats 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytosol
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding	Enzyme Inhibitor Activity Protein Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Viral Process Wnt Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Glucose Metabolic Process Regulation Of Cell Size Protein Ubiquitination Cellular Response To Insulin Stimulus Multicellular Organism Growth Negative Regulation Of Catalytic Activity Negative Regulation Of Fatty Acid Biosynthetic Process Cellular Chemical Homeostasis
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: ABL1 BRAP CDT1 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DTL DYRK2 ERCC8 GPS1 HIST1H1C HIST1H3A HOXD3 IP6K1 LMO4 MAFB MEF2A PIN1 RASSF1 RBX1 SALL2 SIN3A SKP2 STAT1 SUPT3H TP53 UNG USP40 VAMP3 WDTC1 XPA ZNF277	3 interactors: DDB1 MED23 MED4
Entrez ID		1642	23038
HPRD ID		10952	10307
Ensembl ID		ENSG00000167986	ENSG00000142784
Uniprot IDs		Q16531	Q8N5D0
PDB IDs		2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4E54 4E5Z	3I7N
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cullin Deneddylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination DNA Repair Protein Deneddylation Heterocycle Metabolic Process Protein Modification By Small Protein Conjugation Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Protein Modification By Small Protein Removal Nitrogen Compound Metabolic Process Response To UV Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Protein Monoubiquitination Immune System Development Cellular Response To Stimulus Metabolic Process Catabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Response To Radiation Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Process Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Protein Metabolic Process Cellular Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation By Virus Of Viral Protein Levels In Host Cell UV-damage Excision Repair Positive Regulation Of Viral Release From Host Cell Histone H2A Monoubiquitination Histone H2A Ubiquitination Nucleotide-excision Repair, DNA Damage Removal Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Transcription From RNA Polymerase II Promoter Interaction With Symbiont Histone Ubiquitination Androgen Receptor Signaling Pathway Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	a8 abcc5 acvr2 biallelic crcs driver frameshift g8 glyr1 harbored intronic know microsatellite mismatch mononucleotide msh3 msi or51e2 passengers repeats rock1 suppressors t8 t9 tceb3 tgfbr2 tumourigenesis unbiased whenever
Tagcloud (Difference) ?		accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization	a8 abcc5 acvr2 biallelic crcs driver frameshift g8 glyr1 harbored intronic know microsatellite mismatch mononucleotide msh3 msi or51e2 passengers repeats rock1 suppressors t8 t9 tceb3 tgfbr2 tumourigenesis unbiased whenever
Tagcloud (Intersection) ?