TRIM54 and MAD2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM54	MAD2L2
Description		tripartite motif containing 54	mitotic arrest deficient 2 like 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Z Disc	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell Differentiation Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		318 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIRIM AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf216 C1orf35 C1QTNF2 C2orf49 C8orf74 CALM3 CARD9 CATSPERT CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC187 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRC4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1	47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		57159	10459
HPRD ID		05928	07246
Ensembl ID		ENSG00000138100	ENSG00000116670
Uniprot IDs		Q9BYV2	Q9UI95
PDB IDs		3Q1D	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Cysteine-type Deubiquitinase Activity Protein Binding Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Keratin Filament Post-translational Protein Modification Ubiquitin Binding Cytosol Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Protein Modification Process Intermediate Filament-based Process Protein K48-linked Deubiquitination Keratinization Organelle Organization Cytoplasm Intermediate Filament Ubiquitin Conjugating Enzyme Activity Centrosome Positive Regulation Of Exosomal Secretion Deubiquitinase Activity Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway K48-linked Deubiquitinase Activity Ubiquitin-dependent Protein Catabolic Process Membrane Fission Regulation Of Exosomal Secretion Modification-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of TORC1 Signaling Regulation Of DNA Repair Peptidase Activity Nucleus Proteolysis Microtubule-based Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Regulation Of Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Double-strand Break Repair Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Extracellular Exosome Assembly DeNEDDylase Activity Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Cytoskeleton Microtubule-based Movement Endosome Organization	Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?