TRIM54 and USP33

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		TRIM54	USP33
Gene Name		tripartite motif containing 54	ubiquitin specific peptidase 33
Image
Gene Ontology Annotations	Cellular Component	Microtubule Microtubule Associated Complex Z Disc	Cytoplasm Autophagic Vacuole Golgi Apparatus Centrosome VCB Complex Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Microtubule Binding Zinc Ion Binding	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ral GTPase Binding Ubiquitin Binding
	Biological Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organismal Development Cell Differentiation	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Centrosome Duplication Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		127 interactors: ADCY4 ALS2CR11 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC67 CCDC87 CDK18 CDKN1A CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM STRA13 TBC1D22B TCEA2 TCEB3 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D3 UBE2I UBE2U UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 WDYHV1 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587	14 interactors: ARRB2 CCP110 DDX56 DIO2 EIF6 SELENBP1 TCEB1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		57159	23032
HPRD ID		05928	10297
Ensembl ID		ENSG00000138100	ENSG00000077254
Uniprot IDs		Q9BYV2	Q8TEY7
PDB IDs		3Q1D	2UZG
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Proteolysis Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Organelle Organization Regulation Of Protein Catabolic Process Protein Metabolic Process Histone Deubiquitination RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Process Monoubiquitinated Protein Deubiquitination Histone Modification Gene Expression RNA Biosynthetic Process Chromatin Modification Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromatin Organization Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Chromosome Organization Cellular Response To Heat Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cellular Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Proteolysis Protein Deubiquitination Cellular Response To Oxygen Levels Protein Modification By Small Protein Removal Histone Deubiquitination Regulation Of Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Hypoxia Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2B Conserved C-terminal Lysine Deubiquitination Thyroid Hormone Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Gene Expression
Tagcloud ?			autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation
Tagcloud (Difference) ?			autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation
Tagcloud (Intersection) ?