UQCRC1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		UQCRC1	TRIM63
Gene Name		ubiquinol-cytochrome c reductase core protein I	tripartite motif containing 63, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex III	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Ubiquinol-cytochrome-c Reductase Activity Protein Complex Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Respiratory Electron Transport Chain Response To Alkaloid Cellular Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Hydrogen Ion Transmembrane Transport	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CYCS HNRNPD RTN4 TRIM63 UQCRC2	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		7384	84676
HPRD ID		01875	05843
Ensembl ID		ENSG00000010256	ENSG00000158022
Uniprot IDs		P31930	B4DN95 Q969Q1
PDB IDs			2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Oxidative Phosphorylation Respiratory Electron Transport Chain Electron Transport Chain ATP Metabolic Process Cellular Macromolecule Catabolic Process Cellular Respiration Regulation Of Branching Morphogenesis Of A Nerve Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Electron Transport, Cytochrome C To Oxygen Purine Nucleoside Metabolic Process Skeletal Muscle Atrophy Circadian Regulation Of Translation Striated Muscle Atrophy Ribonucleotide Metabolic Process Muscle Atrophy Endoplasmic Reticulum Tubular Network Organization Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Ribose Phosphate Metabolic Process Skeletal Muscle Adaptation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Generation Of Precursor Metabolites And Energy Aromatic Compound Catabolic Process Catabolic Process Apoptotic DNA Fragmentation Axonal Fasciculation Negative Regulation Of Axon Extension Nucleotide Metabolic Process Cardiac Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Cellular Response To Dexamethasone Stimulus Nucleobase-containing Small Molecule Metabolic Process Response To Dexamethasone Neuron Recognition Response To Electrical Stimulus Cerebral Cortex Radial Glia Guided Migration Endoplasmic Reticulum Organization Regulation Of MRNA Stability Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Regulation Of RNA Stability Epithelial To Mesenchymal Transition	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?			benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?			benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?