UQCRC1 and CYCS

Number of citations of the paper that reports this interaction (PubMedID 6251869)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		UQCRC1	CYCS
Description		ubiquinol-cytochrome c reductase core protein 1	cytochrome c, somatic
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Apoptosome
	Molecular Function	Protein Binding Quinol-cytochrome-c Reductase Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Response To Alkaloid Cellular Respiration Proton Transmembrane Transport	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Cellular Respiration Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Respiratory electron transport Complex III assembly Complex III assembly	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Metabolite levels ( 23823483) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		11 interacting genes: BDKRB1 CYCS DSCAM ERCC6 HNRNPD KRAS NLGN3 OGT RTN4 TRIM63 UQCRC2	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		7384	54205
HPRD ID		01875	00479
Ensembl ID		ENSG00000010256	ENSG00000172115
Uniprot IDs		P31930	G4XXL9 P99999
PDB IDs		5XTE 5XTH 5XTI	1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ 6XNK
Enriched GO Terms of Interacting Partners?		Regulation Of Rac Protein Signal Transduction Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Myoblast Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rac Protein Signal Transduction Response To Lipid Regulation Of Nervous System Development Regulation Of Synapse Assembly Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Phosphorus Metabolic Process Social Behavior Neuron Recognition Protein Tyrosine Kinase Binding Synapse Response To Gamma Radiation Intrinsic Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Response To Hormone Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cell Junction Assembly Regulation Of Glycolytic Process Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Nervous System Development Cellular Response To Glucose Stimulus Positive Regulation Of Gene Expression Regulation Of Carbohydrate Catabolic Process Bradykinin Receptor Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Cellular Developmental Process Positive Regulation Of Developmental Process Apoptotic Signaling Pathway Response To Light Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Carbohydrate Stimulus Striated Muscle Cell Differentiation Circadian Regulation Of Translation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction	Electron Transport Chain Mitochondrial Outer Membrane Mitochondrion Neuron Apoptotic Process Generation Of Precursor Metabolites And Energy Mitochondrial Membrane Apoptosome Dendritic Cell Apoptotic Process Respiratory Electron Transport Chain Mitochondrial Membrane Organization Mitochondrion Organization Quinol-cytochrome-c Reductase Activity FAD Binding BH3 Domain Binding Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Bcl-2 Family Protein Complex Electron Transfer Activity Intrinsic Apoptotic Signaling Pathway Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Pore Complex Aerobic Electron Transport Chain Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Steroid Biosynthetic Process Mitochondrial Inner Membrane Response To Alkaloid Platelet Alpha Granule Membrane Aerobic Respiration Negative Regulation Of Anoikis Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Programmed Cell Death Involved In Cell Development Cellular Respiration Oxidative Phosphorylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cytosol Positive Regulation Of Apoptotic Process Regulation Of Anoikis Ubiquitin Protein Ligase Binding Sterol Metabolic Process Protein Refolding Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway
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