UQCRC1

Name	ubiquinol-cytochrome c reductase core protein 1
Structure
Novel Interactors	1 novel interactors: GPX1
Interactors	11 interactors: BDKRB1 CYCS DSCAM ERCC6 HNRNPD KRAS NLGN3 OGT RTN4 TRIM63 UQCRC2
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Protein Binding Quinol-cytochrome-c Reductase Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Response To Alkaloid Cellular Respiration Proton Transmembrane Transport
Pathways	Respiratory electron transport Complex III assembly Complex III assembly
Drugs	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
GWAS	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Metabolite levels ( 23823483 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	7384
HPRD ID	01875
Ensembl ID	ENSG00000010256
Uniprot IDs	P31930
PDB IDs	5XTE 5XTH 5XTI
GO Terms Enriched among Interactors ?	Regulation Of Rac Protein Signal Transduction Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Myoblast Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rac Protein Signal Transduction Response To Lipid Regulation Of Nervous System Development Regulation Of Synapse Assembly Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Phosphorus Metabolic Process Social Behavior Neuron Recognition Protein Tyrosine Kinase Binding Synapse Response To Gamma Radiation Intrinsic Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Response To Hormone Response To Electrical Stimulus Hepatocyte Dedifferentiation Cellular Response To Putrescine Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cell Junction Assembly Regulation Of Glycolytic Process Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Positive Regulation Of Nervous System Development Cellular Response To Glucose Stimulus Positive Regulation Of Gene Expression Regulation Of Carbohydrate Catabolic Process Bradykinin Receptor Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Cellular Developmental Process Positive Regulation Of Developmental Process Apoptotic Signaling Pathway Response To Light Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Carbohydrate Stimulus Striated Muscle Cell Differentiation Circadian Regulation Of Translation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction