UQCRC1 and RTN4

Number of citations of the paper that reports this interaction (PMID 12067236)
13

Data Source:
HPRD (in vivo, two hybrid)

		UQCRC1	RTN4
Gene Name		ubiquinol-cytochrome c reductase core protein I	reticulon 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex III	Intracellular Nuclear Envelope Endoplasmic Reticulum Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Ubiquinol-cytochrome-c Reductase Activity Protein Complex Binding Metal Ion Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Response To Activity Respiratory Electron Transport Chain Response To Alkaloid Cellular Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Hydrogen Ion Transmembrane Transport	Angiogenesis Apoptotic Process Axonal Fasciculation Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Cardiac Epithelial To Mesenchymal Transition Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Myxothiazol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2
Diseases
GWAS			Obesity (extreme) ( 19553259)
Protein-Protein Interactions		5 interactors: CYCS HNRNPD RTN4 TRIM63 UQCRC2	34 interactors: ARL6IP1 BAIAP2 BCL2 BCL2L1 CLN8 CNTNAP1 COL4A3BP CRMP1 FXR2 HLA-DPB1 LAMA4 LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		7384	57142
HPRD ID		01875	07259
Ensembl ID		ENSG00000010256	ENSG00000115310
Uniprot IDs		P31930	Q9NQC3
PDB IDs			2G31 2JV5
Enriched GO Terms of Interacting Partners?		Oxidative Phosphorylation Respiratory Electron Transport Chain Electron Transport Chain ATP Metabolic Process Cellular Macromolecule Catabolic Process Cellular Respiration Regulation Of Branching Morphogenesis Of A Nerve Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Electron Transport, Cytochrome C To Oxygen Purine Nucleoside Metabolic Process Skeletal Muscle Atrophy Circadian Regulation Of Translation Striated Muscle Atrophy Ribonucleotide Metabolic Process Muscle Atrophy Endoplasmic Reticulum Tubular Network Organization Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Ribose Phosphate Metabolic Process Skeletal Muscle Adaptation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Generation Of Precursor Metabolites And Energy Aromatic Compound Catabolic Process Catabolic Process Apoptotic DNA Fragmentation Axonal Fasciculation Negative Regulation Of Axon Extension Nucleotide Metabolic Process Cardiac Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Cellular Response To Dexamethasone Stimulus Nucleobase-containing Small Molecule Metabolic Process Response To Dexamethasone Neuron Recognition Response To Electrical Stimulus Cerebral Cortex Radial Glia Guided Migration Endoplasmic Reticulum Organization Regulation Of MRNA Stability Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Regulation Of RNA Stability Epithelial To Mesenchymal Transition	Transport Establishment Of Localization In Cell Membrane Organization Cell Part Morphogenesis Intracellular Transport Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitochondrial Membrane Organization Regulation Of Telomere Maintenance Via Telomerase Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Anoikis Regulation Of Telomerase Activity Neuromuscular Process Controlling Posture Regulation Of Anoikis Regulation Of Telomere Maintenance Immune Response-regulating Signaling Pathway RNA-dependent DNA Replication Regulation Of Autophagy Mitochondrion Morphogenesis Cell Morphogenesis Negative Regulation Of DNA Biosynthetic Process Vesicle-mediated Transport Immune Response-activating Cell Surface Receptor Signaling Pathway System Development Neuron Differentiation Nervous System Development Axonogenesis Release Of Cytochrome C From Mitochondria Regulation Of Cellular Component Organization Cell Projection Morphogenesis Telomere Maintenance Via Telomere Lengthening Antigen Receptor-mediated Signaling Pathway Generation Of Neurons Anatomical Structure Development Aging Axon Development Developmental Process Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Response To Alkaloid Regulation Of Mitochondrial Membrane Permeability Cell Morphogenesis Involved In Neuron Differentiation Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Membrane Permeability Neurogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?			advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Difference) ?			advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Intersection) ?