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SUMO1 and TOP1
Number of citations of the paper that reports this interaction (PubMedID
12439742
)
0
Data Source:
HPRD
(in vitro, in vivo)
SUMO1
TOP1
Description
small ubiquitin like modifier 1
DNA topoisomerase I
Image
GO Annotations
Cellular Component
XY Body
Nucleus
Nuclear Pore
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Membrane
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Nuclear Chromosome
P-body
Fibrillar Center
Dense Fibrillar Component
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Protein-DNA Complex
Perikaryon
Molecular Function
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Transporter Activator Activity
Ubiquitin-specific Protease Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
RNA Binding
DNA Topoisomerase Activity
DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
DNA Binding, Bending
Isomerase Activity
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Supercoiled DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Regulation Of DNA-templated Transcription
Protein Sumoylation
PML Body Organization
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of DNA-templated Transcription
Protein Stabilization
Roof Of Mouth Development
Cellular Response To Cadmium Ion
Regulation Of Cardiac Muscle Cell Contraction
Protein Localization To Nuclear Pore
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Regulation Of Calcium Ion Transmembrane Transport
DNA Replication
DNA Topological Change
Chromatin Remodeling
Chromosome Segregation
Circadian Rhythm
Response To Temperature Stimulus
RRNA Transcription
Response To Xenobiotic Stimulus
Response To Gamma Radiation
Programmed Cell Death
Peptidyl-serine Phosphorylation
Animal Organ Regeneration
Circadian Regulation Of Gene Expression
Embryonic Cleavage
Rhythmic Process
Response To CAMP
Cellular Response To Luteinizing Hormone Stimulus
Pathways
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Transcriptional and post-translational regulation of MITF-M expression and activity
SUMOylation of DNA replication proteins
Drugs
Irinotecan
Dactinomycin
Doxorubicin
Topotecan
Camptothecin
Edotecarin
Lucanthone
Elsamitrucin
7-ethyl-10-hydroxycamptothecin
Sodium stibogluconate
Cositecan
XMT-1001
Rubitecan
2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Hexylresorcinol
Sacituzumab govitecan
Trastuzumab deruxtecan
Diseases
GWAS
Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) (
28560309
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Brain morphology (MOSTest) (
32665545
)
Cholesterol, total (
24097068
20686565
)
Hemoglobin (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
LDL cholesterol (
20686565
24097068
)
LDL cholesterol levels (
28334899
)
LDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
LDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Male-pattern baldness (
28196072
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Total cholesterol levels (
28334899
)
Urate levels (
31578528
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
154 interacting genes:
AR
ARK2N
ARRB2
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CEBPA
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
ISG15
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SMARCAD1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
ZBED1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
59 interacting genes:
APAF1
APP
ATM
BARD1
BRCA1
BRD2
BTBD1
BTBD2
BUB3
CASP3
CASP6
CDK8
CEBPA
CKAP5
CSNK2A1
CSNK2A2
DDB2
ELK3
ERCC8
ERG
FSHR
GEMIN4
IL7R
IRF4
IRF8
IRF9
JAK1
JUN
LIG4
LSM4
MDM2
NCL
NCOA6
PDE10A
PIAS4
PPP2R2B
PRB1
PYGM
RBL1
RBL2
RCVRN
SF3B1
SFPQ
SNW1
SRPK2
SRSF1
SRSF11
SUMO1
SYMPK
TARBP2
TDP1
TIAM1
TOPORS
TP53
TRIM32
TUBD1
U2AF2
UBE2I
XRCC5
Entrez ID
7341
7150
HPRD ID
03554
00535
Ensembl ID
ENSG00000116030
ENSG00000198900
Uniprot IDs
B8ZZN6
B9A032
P63165
P11387
Q9BVT2
PDB IDs
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6TRW
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
6XOG
6XOH
6XOI
8DJH
8DJI
8ODR
9B62
1A31
1A35
1A36
1EJ9
1K4S
1K4T
1LPQ
1NH3
1R49
1RR8
1RRJ
1SC7
1SEU
1T8I
1TL8
Enriched GO Terms of Interacting Partners
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Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
PML Body
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Protein Sumoylation
Positive Regulation Of DNA-templated Transcription
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Chromatin
Positive Regulation Of Transcription By RNA Polymerase II
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Chromatin Binding
DNA Damage Response
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Macromolecule Metabolic Process
Response To Stress
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nuclear Body
Protein-containing Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleoplasm
Nucleus
DNA Damage Response
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Regulation Of RNA Metabolic Process
Macromolecule Metabolic Process
DNA Repair
Response To Ionizing Radiation
Response To Radiation
Nucleobase-containing Compound Metabolic Process
Response To Stress
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Regulation Of Macromolecule Biosynthetic Process
Response To X-ray
Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Chromatin
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
MRNA Metabolic Process
Cellular Response To Radiation
Positive Regulation Of Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway
DNA Metabolic Process
DNA Topoisomerase Binding
Nuclear Speck
Cellular Developmental Process
Positive Regulation Of Apoptotic Process
Transcription Cis-regulatory Region Binding
Negative Regulation Of Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein-RNA Complex Assembly
Protein Polyubiquitination
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Tagcloud (Intersection)
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