SUMO1 and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		SUMO1	AXIN1
Description		small ubiquitin like modifier 1	axin 1
Image
GO Annotations	Cellular Component	XY Body Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome
	Molecular Function	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Activity Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Transporter Activator Activity Ubiquitin-specific Protease Binding	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Protein Sumoylation PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of DNA-templated Transcription Protein Stabilization Roof Of Mouth Development Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Formation of Incision Complex in GG-NER Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SUMOylation of nuclear envelope proteins PKR-mediated signaling Transcriptional and post-translational regulation of MITF-M expression and activity	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Caudal duplication anomaly Hepatocellular carcinoma
GWAS			Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		154 interacting genes: AR ARK2N ARRB2 ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CEBPA CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 ISG15 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SMARCAD1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN ZBED1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451	91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19
Entrez ID		7341	8312
HPRD ID		03554	04819
Ensembl ID		ENSG00000116030	ENSG00000103126
Uniprot IDs		B8ZZN6 B9A032 P63165	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6TRW 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3 6XOG 6XOH 6XOI 8DJH 8DJI 8ODR 9B62	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process PML Body Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Sumoylation Positive Regulation Of DNA-templated Transcription Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Chromatin Binding DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Metabolic Process Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Body Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process
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