SUMO1 and MEF2A

Number of citations of the paper that reports this interaction (PMID 16484498)
132

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo)

		SUMO1	MEF2A
Gene Name		small ubiquitin-like modifier 1	myocyte enhancer factor 2A
Image
Gene Ontology Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm PML Body Nuclear Speck Dendrite Nuclear Membrane Synapse	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Binding Transcription Factor Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity
	Biological Process	DNA Repair Protein Sumoylation Cytokine-mediated Signaling Pathway PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Palate Development Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Localization To Nuclear Pore	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		Interferon gamma signaling SUMO is proteolytically processed Post-translational protein modification SUMOylation Interferon Signaling Cytokine Signaling in Immune system SUMO is conjugated to E1 (UBA2:SAE1) Regulation of IFNG signaling SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		194 interactors: ADD3 APP AR ARL13A ATF2 ATF3 ATXN1 ATXN3 ATXN7 AURKA AURKB BCAM BCL11A BIRC3 BLM BRCA1 C11orf65 C18orf25 CAMSAP2 CARD9 CASP2 CASP8 CCDC67 CD40 CDCA8 CHAF1A CHD3 CHD4 COG1 CTNNA1 DAXX DDX24 DNM1 DNMT3A DNMT3B DTX2 EDARADD ESR1 ETV1 ETV4 ETV6 FADD FAM118B FANCM FAS FASLG FBF1 FLI1 FOS FOXL2 FOXM1 GATA1 GLP1R GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HIRA HNF4A HNRNPC HNRNPK HSF1 HSF2 HTT ING2 IRAK1 JUN KAT2A KAT6B KDM1A KRT14 KRT18 KRT5 KRT8 MAP2K1 MAPK1IP1L MDC1 MDM2 MECOM MEF2A MEF2C MITF MKL1 MSX1 MUL1 MX1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NELFE NFE2L2 NFKBIA NIN NOS1 NOX5 NR3C1 NR3C2 PARK7 PARP1 PAX6 PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3C3 PLK3 PML PPARA PPM1J RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBM25 RHOXF2 RNF4 RPS3 SAE1 SALL1 SART1 SATB1 SEMA6A SENP1 SENP2 SENP6 SETX SH3KBP1 SLC2A1 SOX10 SOX2 SOX6 SP1 SP100 SP3 SREBF1 SREBF2 SSRP1 STAB2 STK24 STMN2 SUMO1P1 SUMO2 SUPT7L SYMPK TCERG1 TCF4 TDG TDP2 TFCP2 TGM2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRIM5 TRPS1 TSC22D3 TSHZ2 TSNAX UBA2 UBE2I USP25 USP7 USPL1 WNK1 WRN XRCC1 XRCC5 ZBTB16 ZBTB26 ZBTB6 ZBTB7A ZCCHC12 ZCCHC7 ZMYM2 ZMYM5 ZNF24 ZNF451	26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		7341	4205
HPRD ID		03554	02807
Ensembl ID		ENSG00000116030	ENSG00000068305
Uniprot IDs		P63165	Q02078
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP	1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Apoptotic Process Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Organelle Organization Chromosome Organization Cellular Response To Organic Substance Protein Sumoylation Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Developmental Process Programmed Cell Death Apoptotic Process Peptidyl-lysine Modification	Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?