SUMO1 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 16690127)
0

Data Source:
HPRD (in vivo)

		SUMO1	IRAK1
Description		small ubiquitin like modifier 1	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	XY Body Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Activity Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Transporter Activator Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Protein Sumoylation PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of DNA-templated Transcription Protein Stabilization Roof Of Mouth Development Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Formation of Incision Complex in GG-NER Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SUMOylation of nuclear envelope proteins PKR-mediated signaling Transcriptional and post-translational regulation of MITF-M expression and activity	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs			Fostamatinib
Diseases
GWAS			Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		154 interacting genes: AR ARK2N ARRB2 ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CEBPA CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 ISG15 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SMARCAD1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN ZBED1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451	52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2
Entrez ID		7341	3654
HPRD ID		03554	02235
Ensembl ID		ENSG00000116030	ENSG00000184216
Uniprot IDs		B8ZZN6 B9A032 P63165	D3YTB5 P51617
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6TRW 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3 6XOG 6XOH 6XOI 8DJH 8DJI 8ODR 9B62	6BFN
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process PML Body Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Sumoylation Positive Regulation Of DNA-templated Transcription Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Chromatin Binding DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Metabolic Process Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Body Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?