SUMO1 and C11orf65

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SUMO1	C11orf65
Description		small ubiquitin like modifier 1	chromosome 11 open reading frame 65
Image			No pdb structure
GO Annotations	Cellular Component	XY Body Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane
	Molecular Function	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Activity Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Transporter Activator Activity Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Protein Sumoylation PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of DNA-templated Transcription Protein Stabilization Roof Of Mouth Development Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport	Negative Regulation Of Mitochondrial Fission Negative Regulation Of Protein Targeting To Mitochondrion
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Formation of Incision Complex in GG-NER Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SUMOylation of nuclear envelope proteins PKR-mediated signaling Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS			Granulocyte count ( 27863252) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular volume ( 32888494 29403010) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Nonunion in individuals with fractures ( 30680360) Platelet count ( 27863252) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Uterine fibroids ( 31649266 30194396) White blood cell count ( 27863252 32888494)
Interacting Genes		154 interacting genes: AR ARK2N ARRB2 ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CEBPA CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 ISG15 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SMARCAD1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN ZBED1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451	7 interacting genes: ATOSB CALM1 CALM2 CALM3 CALML3 DAPK1 SUMO1
Entrez ID		7341	160140
HPRD ID		03554	14579
Ensembl ID		ENSG00000116030	ENSG00000166323
Uniprot IDs		B8ZZN6 B9A032 P63165	Q8NCR3
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6TRW 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3 6XOG 6XOH 6XOI 8DJH 8DJI 8ODR 9B62
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process PML Body Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Sumoylation Positive Regulation Of DNA-templated Transcription Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Chromatin Binding DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Metabolic Process Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Body Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Detection Of Calcium Ion Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Negative Regulation Of Transporter Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Cation Transmembrane Transport Titin Binding Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Monoatomic Cation Transmembrane Transport Protein Phosphatase Activator Activity Calyx Of Held Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Striated Muscle Contraction Negative Regulation Of Monoatomic Ion Transport Catalytic Complex Detection Of Chemical Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Metal Ion Negative Regulation Of Transmembrane Transport Calcium Channel Complex Regulation Of Metal Ion Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Sequestering Of Calcium Ion Synaptic Vesicle Membrane Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transmembrane Transport Calcium-mediated Signaling Regulation Of Muscle Contraction Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of Heart Contraction
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