MAP3K14 and EDAR

Number of citations of the paper that reports this interaction (PubMedID 11035039)
0

Data Source:
HPRD (in vivo)

		MAP3K14	EDAR
Description		mitogen-activated protein kinase kinase kinase 14	ectodysplasin A receptor
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31361310 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Beard thickness ( 26926045) Blood protein levels ( 30072576) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B
Entrez ID		9020	10913
HPRD ID		05230	04974
Ensembl ID		ENSG00000006062	ENSG00000135960
Uniprot IDs		Q99558	Q9UNE0
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW	7X9G
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding TORC2 Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Trachea Gland Development TRC Complex Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response Apical Plasma Membrane Urothelial Plaque Death Receptor Agonist Activity BAT3 Complex Binding Sphingolipid Binding Response To External Biotic Stimulus IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Hair Follicle Placode Formation Salivary Gland Cavitation CD27 Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of ERAD Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of JUN Kinase Activity Ubiquitin-protein Transferase Activity Immune System Process
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