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MAP3K14 and RPL30
Number of citations of the paper that reports this interaction (PubMedID
14743216
)
0
Data Source:
HPRD
(in vitro)
MAP3K14
RPL30
Description
mitogen-activated protein kinase kinase kinase 14
ribosomal protein L30
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Cytosol
Ribosome
Focal Adhesion
Postsynaptic Density
Membrane
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Synapse
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Biological Process
MAPK Cascade
Immune Response
Non-canonical NF-kappaB Signal Transduction
Defense Response To Virus
Cellular Response To Mechanical Stimulus
Cytoplasmic Translation
Translation
Killing Of Cells Of Another Organism
Defense Response To Gram-negative Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
31361310
31619474
31959851
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Cognitive function (
28093568
)
Joint damage in rheumatoid arthritis (
26498133
)
Male-pattern baldness (
28196072
)
Multiple sclerosis (
21833088
31604244
)
Multiple sclerosis and LDL levels (pleiotropy) (
26920376
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Plateletcrit (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
42 interacting genes:
ALPL
BIRC3
BRCA1
CASP8
CDC37
CHUK
EDAR
EEF1A1
EGFR
ELP1
FBL
GRB10
GRB14
GRB7
HSP90AA1
HSP90AB1
IKBKB
IKBKG
MAP2K4
MAP3K7
MAP3K8
MAPK3
NFKB2
NFKBIA
PEBP1
PELI3
RIPK1
RPL30
RPL4
RPL5
RPL6
RPS11
RPS13
SLC9A1
TRAF1
TRAF2
TRAF3
TRAF5
TRAF6
TRIM55
TRIM63
ZFP91
16 interacting genes:
APP
CASP2
DUX4
ERCC6
FAM120B
G0S2
IL7R
MAP2K7
MAP3K14
NEDD4L
NFKB2
OAS1
OGT
PTEN
USP40
ZFAND2A
Entrez ID
9020
6156
HPRD ID
05230
01595
Ensembl ID
ENSG00000006062
ENSG00000156482
Uniprot IDs
Q99558
P62888
PDB IDs
4DN5
4G3D
4IDT
4IDV
6WPP
6Z1Q
6Z1T
8YHW
3VI6
4UG0
4V6X
5AJ0
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7BHP
7F5S
7OW7
7QVP
7XNX
7XNY
8A3D
8FKY
8FKZ
8FL2
8FL3
8FL4
8FL6
8FL7
8FL9
8FLA
8FLB
8FLC
8FLD
8FLE
8FLF
8G5Y
8G5Z
8G60
8G61
8G6J
8GLP
8IDT
8IDY
8IE3
8IFD
8IFE
8INE
8INF
8INK
8IPD
8IPX
8IPY
8IR1
8IR3
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8RL2
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
Enriched GO Terms of Interacting Partners
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Tumor Necrosis Factor-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Receptor Complex
Intracellular Signaling Cassette
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Signal Transduction
Cytosol
Tumor Necrosis Factor Receptor Binding
Cytoplasm
Positive Regulation Of DNA-binding Transcription Factor Activity
Response To Cytokine
Response To Peptide
Response To Tumor Necrosis Factor
Regulation Of Cell Communication
Regulation Of Signaling
Identical Protein Binding
Signaling Adaptor Activity
Regulation Of Intracellular Signal Transduction
Cytosolic Ribosome
Response To External Biotic Stimulus
Cellular Response To Tumor Necrosis Factor
Regulation Of Protein Metabolic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Interleukin-1-mediated Signaling Pathway
Thioesterase Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Primary Metabolic Process
Ubiquitin Protein Ligase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Scaffold Protein Binding
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
Transferase Activity
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Regulation Of Defense Response
Toll-like Receptor 4 Signaling Pathway
Focal Adhesion
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Rhythmic Process
Cytosol
Enzyme Binding
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Proteolysis
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Protein Catabolic Process
Molecular Function Activator Activity
Positive Regulation Of Signal Transduction
Dendritic Spine
Reproductive Behavior
Regulation Of Generation Of Precursor Metabolites And Energy
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Peptidyl-serine Phosphorylation
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of RNA Biosynthetic Process
Hemopoiesis
Positive Regulation Of DNA-templated Transcription
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Amyloid-beta Complex
Dendritic Shaft
Growth Cone Lamellipodium
Neuron Projection Organization
Cellular Developmental Process
Regulation Of Response To Calcium Ion
Positive Regulation Of Cell Communication
Amylin Binding
Positive Regulation Of Signaling
Positive Regulation Of Toll Signaling Pathway
Regulation Of CAMP/PKA Signal Transduction
Response To Mechanical Stimulus
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Synaptic Vesicle Clustering
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Regulation Of Signal Transduction
Positive Regulation Of RNA Metabolic Process
Neuron Projection Development
Modulation Of Excitatory Postsynaptic Potential
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