MAP3K14 and GRB7

Number of citations of the paper that reports this interaction (PMID 12853971)
13

Data Source:
HPRD (in vivo)

		MAP3K14	GRB7
Gene Name		mitogen-activated protein kinase kinase kinase 14	growth factor receptor-bound protein 7
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Signal Transduction By Phosphorylation T Cell Costimulation NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Mechanical Stimulus	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration
Pathways		Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Adaptive Immune System	Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		39 interactors: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKAP IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91	39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16
Entrez ID		9020	2886
HPRD ID		05230	03311
Ensembl ID			ENSG00000141738
Uniprot IDs		Q99558	Q14451
PDB IDs		4DN5 4G3D 4IDT 4IDV	1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Fc Receptor Signaling Pathway Defense Response Apoptotic Process Immune System Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Regulation Of Cellular Protein Metabolic Process Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Activation Of Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome	adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?		alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome	adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?