MAP3K14 and RPL5

Number of citations of the paper that reports this interaction (PubMedID 14743126)
0

Data Source:
HPRD (in vivo)

		MAP3K14	RPL5
Description		mitogen-activated protein kinase kinase kinase 14	ribosomal protein L5
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding MRNA 3'-UTR Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding MRNA 5'-UTR Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Gene Expression Ribosomal Large Subunit Biogenesis Positive Regulation Of Translation Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31361310 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Height ( 20881960) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 17660530 19525955)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	32 interacting genes: BCAS2 CLK1 CSNK2A1 CSNK2B DCC EIF5A ERCC6 FOXP1 HARS1 IPO13 IPO5 IPO7 KPNB1 KRT31 MAP3K14 MDM2 NVL OGT PDCD4 PDE4B PPM1D RNA5S7 RNF181 SAYSD1 SPIN1 SPP1 TNIP1 TNPO1 TP73 TSC22D1 UPF2 VHL
Entrez ID		9020	6125
HPRD ID		05230	04699
Ensembl ID		ENSG00000006062	ENSG00000122406
Uniprot IDs		Q99558	A2RUM7 P46777
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction	Protein Localization To Organelle Protein Localization To Nucleus Import Into Nucleus Protein Import Into Nucleus Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Localization Sequence Binding Cytosol Nuclear Pore Ribosomal Protein Import Into Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Establishment Of Protein Localization To Organelle Regulation Of Signaling Negative Regulation Of Developmental Growth Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Nucleoplasm Nucleus Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Proteolysis Negative Regulation Of Gene Expression Double-strand Break Repair Via Classical Nonhomologous End Joining Signal Transduction In Response To DNA Damage Small GTPase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Nucleolus Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Intracellular Protein Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
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