MAP3K14 and RPS13

Number of citations of the paper that reports this interaction (PubMedID 31980649)
68

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MAP3K14	RPS13
Description		mitogen-activated protein kinase kinase kinase 14	ribosomal protein S13
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding
	Biological Process	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus	Cytoplasmic Translation Translation Negative Regulation Of RNA Splicing Ribosomal Small Subunit Biogenesis
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31361310 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Body mass index ( 26426971) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	9 interacting genes: CLIP4 DUX4 MAP3K14 NFKB2 PDCD4 PPIL3 PTEN RBFOX2 SPP1
Entrez ID		9020	6207
HPRD ID		05230	01604
Ensembl ID		ENSG00000006062	ENSG00000110700
Uniprot IDs		Q99558	P62277
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7JQB 7JQC 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction	Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Bcl3/NF-kappaB2 Complex I-kappaB/NF-kappaB Complex Follicular Dendritic Cell Activation Follicular Dendritic Cell Differentiation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Smooth Muscle Cell Proliferation Central Nervous System Myelin Maintenance Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Protein Phosphorylation Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of Phosphorylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Neuron Projection Development Osteoblast Differentiation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Nervous System Development Regulation Of Smooth Muscle Cell Proliferation Phosphatidylinositol Phosphate Phosphatase Activity Androgen Catabolic Process Regulation Of RNA Metabolic Process Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Regulation Of Response To Wounding Cellular Response To Testosterone Stimulus Negative Regulation Of G0 To G1 Transition Negative Regulation Of Cell Projection Organization Regulation Of Nucleobase-containing Compound Metabolic Process Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Size
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