MAP3K14 and ELP1

Number of citations of the paper that reports this interaction (PubMedID 9751059)
0

Data Source:
HPRD (in vitro, in vivo)

		MAP3K14	ELP1
Description		mitogen-activated protein kinase kinase kinase 14	elongator acetyltransferase complex subunit 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	TRNA Binding Protein Binding
	Biological Process	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus	TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Translation TRNA Processing
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	HATs acetylate histones
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31361310 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 21833088 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Appendicular lean mass ( 33097823)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	27 interacting genes: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 ELP6 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		9020	8518
HPRD ID		05230	04763
Ensembl ID		ENSG00000006062	ENSG00000070061
Uniprot IDs		Q99558	A0A6Q8PGW3 A0A6Q8PHA0 B3KNB2 B4E3I9 F5H2T0 O95163 Q8N516
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW	5CQR 8PTX 8PTY 8PTZ 8PU0
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction	Non-canonical NF-kappaB Signal Transduction Elongator Holoenzyme Complex TRNA Wobble Uridine Modification Immune Response-regulating Signaling Pathway Canonical NF-kappaB Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway IkappaB Kinase Activity Fc-epsilon Receptor Signaling Pathway Stress-activated MAPK Cascade Innate Immune Response-activating Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Response To Tumor Necrosis Factor Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway IkappaB Kinase Complex Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Regulation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Transferrin Receptor Binding TRIF-dependent Toll-like Receptor Signaling Pathway Cytosol Scaffold Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Regulation Of Cytokine Production Involved In Inflammatory Response TRNA Modification Protein Serine/threonine Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway
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