MAP3K14 and RPS11

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		MAP3K14	RPS11
Gene Name		mitogen-activated protein kinase kinase kinase 14	ribosomal protein S11
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Structural Constituent Of Ribosome Protein Binding RRNA Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Signal Transduction By Phosphorylation T Cell Costimulation NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Mechanical Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Osteoblast Differentiation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Adaptive Immune System	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Hematological and biochemical traits ( 20139978) Metabolite levels ( 21909109) Serum albumin level ( 23022100) Serum total protein level ( 23022100)
Protein-Protein Interactions		39 interactors: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKAP IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91	4 interactors: APP DUSP10 MAP3K14 RPL30
Entrez ID		9020	6205
HPRD ID		05230	01599
Ensembl ID			ENSG00000142534
Uniprot IDs		Q99558	P62280
PDB IDs		4DN5 4G3D 4IDT 4IDV	3J3A
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Fc Receptor Signaling Pathway Defense Response Apoptotic Process Immune System Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Regulation Of Cellular Protein Metabolic Process Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Activation Of Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Synaptic Growth At Neuromuscular Junction Regulation Of Protein Phosphorylation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Collateral Sprouting In Absence Of Injury MAPK Cascade Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Signal Transduction By Phosphorylation Negative Regulation Of Neurogenesis Regulation Of MAP Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Brown Fat Cell Differentiation Axon Choice Point Recognition Negative Regulation Of Cell Development Cellular Protein Metabolic Process Neuron Remodeling Response To External Stimulus Phosphorylation Regulation Of Respiratory Burst Negative Regulation Of JUN Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process MRNA Metabolic Process Protein Metabolic Process Cellular Copper Ion Homeostasis Negative Regulation Of Oligodendrocyte Differentiation Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Regulation Of MAPK Cascade Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Neurogenesis Negative Regulation Of JNK Cascade Inactivation Of MAPK Activity Negative Regulation Of Cell Differentiation Mating Behavior Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Glial Cell Differentiation RNA Polyadenylation Neuron Recognition
Tagcloud ?		alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Difference) ?		alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps12 rps18 rps3 rps8 secx ugg
Tagcloud (Intersection) ?