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MAP3K14 and RIPK1
Number of citations of the paper that reports this interaction (PubMedID
11116146
)
0
Data Source:
HPRD
(in vivo)
MAP3K14
RIPK1
Description
mitogen-activated protein kinase kinase kinase 14
receptor interacting serine/threonine kinase 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Death-inducing Signaling Complex
Protein-containing Complex
Receptor Complex
Ripoptosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Death Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Death Domain Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Immune Response
Non-canonical NF-kappaB Signal Transduction
Defense Response To Virus
Cellular Response To Mechanical Stimulus
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Inflammatory Response
Response To Oxidative Stress
Signal Transduction
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
Programmed Cell Death
Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
Intracellular Signal Transduction
Peptidyl-serine Autophosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Necroptotic Process
Positive Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Positive Regulation Of Programmed Necrotic Cell Death
Positive Regulation Of Interleukin-6-mediated Signaling Pathway
T Cell Apoptotic Process
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Ripoptosome Assembly
Necroptotic Signaling Pathway
Positive Regulation Of Execution Phase Of Apoptosis
Ripoptosome Assembly Involved In Necroptotic Process
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of MiRNA Processing
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Caspase activation via Death Receptors in the presence of ligand
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
TNF signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IKK complex recruitment mediated by RIP1
Potential therapeutics for SARS
Microbial modulation of RIPK1-mediated regulated necrosis
SARS-CoV-1-mediated effects on programmed cell death
Defective RIPK1-mediated regulated necrosis
Drugs
Fostamatinib
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
30929738
31361310
31619474
31959851
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Cognitive function (
28093568
)
Joint damage in rheumatoid arthritis (
26498133
)
Male-pattern baldness (
28196072
)
Multiple sclerosis (
21833088
31604244
)
Multiple sclerosis and LDL levels (pleiotropy) (
26920376
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Plateletcrit (
32888494
)
Cerebral white matter volume (
31530798
)
Idiopathic osteonecrosis of the femoral head (
28000841
)
Interacting Genes
42 interacting genes:
ALPL
BIRC3
BRCA1
CASP8
CDC37
CHUK
EDAR
EEF1A1
EGFR
ELP1
FBL
GRB10
GRB14
GRB7
HSP90AA1
HSP90AB1
IKBKB
IKBKG
MAP2K4
MAP3K7
MAP3K8
MAPK3
NFKB2
NFKBIA
PEBP1
PELI3
RIPK1
RPL30
RPL4
RPL5
RPL6
RPS11
RPS13
SLC9A1
TRAF1
TRAF2
TRAF3
TRAF5
TRAF6
TRIM55
TRIM63
ZFP91
49 interacting genes:
ANKRD13A
CASP8
CCDC50
CDC42BPB
CFLAR
CRADD
CTNNB1
EGFR
FADD
FAS
HSP90AA1
IKBKE
IKBKG
ITCH
MAP3K14
MAP3K3
MAP3K8
MTDH
NFKB1
NUMBL
OTUD1
PPDPF
PTK2
RIPK3
RNF11
RNF216
RPA1
SQSTM1
TAX1BP1
TBK1
TICAM1
TNF
TNFAIP3
TNFRSF10A
TNFRSF10B
TNFRSF1A
TRADD
TRAF1
TRAF2
TRAF3
TRAF5
TRAF6
TRIM38
TRIM72
TRPC4AP
UBE2N
USP21
YOD1
ZFAND5
Entrez ID
9020
8737
HPRD ID
05230
04583
Ensembl ID
ENSG00000006062
ENSG00000137275
Uniprot IDs
Q99558
Q13546
PDB IDs
4DN5
4G3D
4IDT
4IDV
6WPP
6Z1Q
6Z1T
8YHW
4ITH
4ITI
4ITJ
4NEU
5HX6
5TX5
5V7Z
6AC5
6C3E
6C4D
6HHO
6NW2
6NYH
6OCQ
6R5F
6RLN
7CJB
7FCZ
7FD0
7XMK
7YDX
8I2N
Enriched GO Terms of Interacting Partners
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Tumor Necrosis Factor-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Receptor Complex
Intracellular Signaling Cassette
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Signal Transduction
Cytosol
Tumor Necrosis Factor Receptor Binding
Cytoplasm
Positive Regulation Of DNA-binding Transcription Factor Activity
Response To Cytokine
Response To Peptide
Response To Tumor Necrosis Factor
Regulation Of Cell Communication
Regulation Of Signaling
Identical Protein Binding
Signaling Adaptor Activity
Regulation Of Intracellular Signal Transduction
Cytosolic Ribosome
Response To External Biotic Stimulus
Cellular Response To Tumor Necrosis Factor
Regulation Of Protein Metabolic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Interleukin-1-mediated Signaling Pathway
Thioesterase Binding
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Primary Metabolic Process
Ubiquitin Protein Ligase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Scaffold Protein Binding
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
Transferase Activity
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Regulation Of Defense Response
Toll-like Receptor 4 Signaling Pathway
Focal Adhesion
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Cell Death
Programmed Cell Death
Tumor Necrosis Factor-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Mechanical Stimulus
Tumor Necrosis Factor Receptor Binding
Positive Regulation Of Defense Response
Response To Mechanical Stimulus
Non-canonical NF-kappaB Signal Transduction
Signaling Adaptor Activity
Apoptotic Signaling Pathway
Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Intracellular Signal Transduction
Activation Of Immune Response
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Death-inducing Signaling Complex
Regulation Of Defense Response
Regulation Of Immune Response
Response To Virus
Positive Regulation Of Immune Response
Immune System Process
TRAIL-activated Apoptotic Signaling Pathway
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Response To External Biotic Stimulus
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Activation Of Innate Immune Response
Regulation Of Cell Communication
Defense Response
Immune Response-activating Signaling Pathway
Positive Regulation Of DNA-binding Transcription Factor Activity
Response To Other Organism
Positive Regulation Of Innate Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
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