CASP6 and PRKCZ

Number of citations of the paper that reports this interaction (PMID 11016947)
19

Data Source:
HPRD (in vitro)

		CASP6	PRKCZ
Gene Name		caspase 6, apoptosis-related cysteine peptidase	protein kinase C, zeta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Filamentous Actin Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Phospholipase Binding Insulin Receptor Substrate Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Long-term Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Platelet Activation Negative Regulation Of Protein Complex Assembly Actin Cytoskeleton Reorganization Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-4 Production Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Negative Regulation Of Hydrolase Activity Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-10 Secretion
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF GPVI-mediated activation cascade Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Height ( 20881960) Reasoning ( 21107309)
Protein-Protein Interactions		38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	84 interactors: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B HABP4 HIST1H1A HIST1H1B HIST3H3 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		839	5590
HPRD ID		03321	01504
Ensembl ID		ENSG00000138794	ENSG00000067606
Uniprot IDs		P55212	Q05513
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Defense Response Fc Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Signaling Fc-epsilon Receptor Signaling Pathway Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Communication Apoptotic Signaling Pathway Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Death Apoptotic Process Response To Fibroblast Growth Factor Vascular Endothelial Growth Factor Receptor Signaling Pathway Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Difference) ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	apical blastocyst cdx2 compaction dampened derives erm gtpases hippo icm lats1 lineages llgl1 nanog outer pard6b phosphorylating polarity polarization rho rock scrib segregation specification specifying te trophectoderm tyrosinated yap
Tagcloud (Intersection) ?