CASP6 and MAPT

Number of citations of the paper that reports this interaction (PubMedID 15356202)
52

Data Source:
BioGRID (enzymatic study, enzymatic study)
HPRD (in vivo, in vitro)

		CASP6	MAPT
Description		caspase 6	microtubule associated protein tau
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Protein-folding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Activation Of Innate Immune Response Proteolysis Apoptotic Process Protein Autoprocessing Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Maturation Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Staurosporine Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process	Microtubule Cytoskeleton Organization Microglial Cell Activation DNA Damage Response Cell-cell Signaling Synapse Assembly Learning Or Memory Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Protein Homooligomerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Localization Negative Regulation Of Tubulin Deacetylation Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Caspase-mediated cleavage of cytoskeletal proteins
Drugs			Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18
Diseases			Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	A body shape index ( 34021172) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701 33861876) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156 31710517) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Left–right brain asymmetry ( 33723403) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 31660654 20070850 20711177 21044948 21292315 34064523 21738487 22438815 24511991 24842889 25064009 28892059 19915575) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 31059154 30089514 21685912) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Subcortical brain region volumes ( 25607358) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		43 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 RNF31 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	127 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CREBBP CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FYN GSK3A GSK3B HDAC6 HNRNPC HOOK3 HSPA8 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK3 MARK4 MASP1 MDM2 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTGES3 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TRIM11 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ
Entrez ID		839	4137
HPRD ID		03321	01142
Ensembl ID		ENSG00000138794	ENSG00000186868
Uniprot IDs		P55212	A0A7I2PJZ2 A0A7I2PLE3 B3KTM0 P10636
PDB IDs		2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV 8EG5 8EG6 8F78 8F96 8F97 8F98 8F99 8F9A 8F9B 8F9C 8F9D 8FBV	1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI 7EYC 7KQK 7MKF 7MKG 7MKH 7NRQ 7NRS 7NRT 7NRV 7NRX 7P65 7P66 7P67 7P68 7P6A 7P6B 7P6C 7P6D 7P6E 7PQC 7PQP 7QJV 7QJW 7QJX 7QJY 7QJZ 7QK1 7QK2 7QK3 7QK5 7QK6 7QKF 7QKG 7QKH 7QKI 7QKJ 7QKK 7QKL 7QKM 7QKU 7QKV 7QKW 7QKX 7QKY 7QKZ 7QL0 7QL1 7QL2 7QL3 7QL4 7R4T 7R5H 7SP1 7U0Z 7UPE 7UPF 7UPG 7YMN 7YPG 8AZU 8BGS 8BGV 8BYN 8CAQ 8CAX 8FNZ 8FUG 8FYU 8G54 8G55 8G58 8GCK 8KDX 8OH2 8OHI 8OHP 8OI0 8OP0 8OPI 8ORE 8ORF 8ORG 8OT6 8OT9 8OTC 8OTG 8OTH 8OTI 8OTJ 8P34 8PII 8PPO 8Q27 8Q2J 8Q2K 8Q2L 8Q7F 8Q7L 8Q7M 8Q7P 8Q7T 8Q88 8Q8C 8Q8D 8Q8E 8Q8F 8Q8L 8Q8M 8Q8R 8Q8S 8Q8U 8Q8V 8Q8W 8Q8X 8Q8Y 8Q8Z 8Q92 8Q97 8Q98 8Q99 8Q9A 8Q9B 8Q9C 8Q9D 8Q9E 8Q9F 8Q9G 8Q9H 8Q9I 8Q9J 8Q9K 8Q9L 8Q9M 8Q9O 8QCP 8QCR 8QDV 8QJJ 8R3T 8SEH 8SEI 8TTL 8TTN 8UQ7 8V1N 8WCP 8ZWL 8ZWM 8ZX6 9B4L 9B4M 9B4N 9B4O 9BBL 9BBM 9BXI 9BXO 9BXQ 9BXR 9CGX 9CGZ 9CZI 9CZL 9EO7 9EO9 9EOE 9EOG 9EOH 9ERM 9ERN 9ERO 9G13 9GG0 9GG1 9GG6 9H5G 9H5J 9HBB 9MR8
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Cytoplasm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleus Ripoptosome CD95 Death-inducing Signaling Complex Response To Stress Programmed Cell Death Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Death-inducing Signaling Complex Cytoskeleton Organization Ubiquitin Protein Ligase Binding Nuclear Matrix Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Modification Process Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Cytosol Regulation Of Protein Metabolic Process Intermediate Filament Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Macromolecule Metabolic Process Cellular Response To Stress Organelle Organization Structural Constituent Of Cytoskeleton Structural Constituent Of Nuclear Lamina Positive Regulation Of Metabolic Process Regulation Of Signaling Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Communication Response To Hypoxia Regulation Of Macroautophagy Positive Regulation Of DNA-binding Transcription Factor Activity Apolipoprotein Binding Death Receptor Binding Astrocyte Activation	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Kinase Activity Protein Modification Process Protein Metabolic Process Tau Protein Binding Intracellular Signal Transduction Protein Phosphorylation Phosphorylation Cytoplasm ATP Binding Cytosol Transferase Activity Nucleotide Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Macromolecule Metabolic Process Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Stress Response To Stress Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Nucleus Positive Regulation Of Cell Communication Regulation Of Protein-containing Complex Assembly Programmed Cell Death Cell Death Apoptotic Process Tau-protein Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Metabolic Process MAP Kinase Activity Regulation Of Immune System Process Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission
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