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CASP6 and DSP
Number of citations of the paper that reports this interaction (PubMedID
15500642
)
0
Data Source:
HPRD
(in vitro)
CASP6
DSP
Description
caspase 6
desmoplakin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cornified Envelope
Nucleus
Cytoplasm
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Fascia Adherens
Intercalated Disc
Membrane
Basolateral Plasma Membrane
Desmosome
Extracellular Exosome
Anchoring Junction
Ficolin-1-rich Granule Membrane
Molecular Function
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Identical Protein Binding
RNA Binding
Protein Kinase C Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Scaffold Protein Binding
Biological Process
Activation Of Innate Immune Response
Proteolysis
Apoptotic Process
Protein Autoprocessing
Epithelial Cell Differentiation
Positive Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Neuron Apoptotic Process
Protein Maturation
Positive Regulation Of Necroptotic Process
Pyroptotic Inflammatory Response
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Response To Staurosporine
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Hepatocyte Apoptotic Process
Desmosome Organization
Ventricular Compact Myocardium Morphogenesis
Epidermis Development
Peptide Cross-linking
Keratinocyte Differentiation
Adherens Junction Organization
Wound Healing
Skin Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Epithelial Cell-cell Adhesion
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Protein Localization To Cell-cell Junction
Pathways
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
RND3 GTPase cycle
RND1 GTPase cycle
Drugs
Zinc
Artenimol
Zinc acetate
Diseases
Striate palmoplantar keratoderma
Skin fragility-woolly hair syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Risk-taking tendency (4-domain principal component model) (
30643258
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Idiopathic pulmonary fibrosis (
29066090
31710517
)
Interstitial lung disease (
23583980
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Numerical cognitive ability (
31620175
)
PR interval (
32439900
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Resting heart rate (
27798624
)
Interacting Genes
43 interacting genes:
APP
CASP10
CASP3
CASP8
CFLAR
CHD3
COPS6
DSP
EIF2S1
HTT
IKBKG
KRT18
LMNA
LMNB1
LNX1
MAPK6
MAPT
NEDD4
NTAQ1
NUAK1
PCYT1A
PIN1
PKIA
PPL
PRKAB2
PRKCZ
PSEN1
PSEN2
PSME3
RB1
RNF31
SATB1
SP1
SRF
SRP72
STUB1
TAB1
TFAP2A
TOP1
TRAF1
UBE4A
UBE4B
VIM
36 interacting genes:
ARID3A
CASP10
CASP2
CASP4
CASP6
CASP7
CASP9
CDC42
CDH5
COL17A1
COPS6
DES
DSC1
ENO3
EVPL
H19
IVL
JUP
KRT1
KRT5
KRT6A
MTDH
PECAM1
PKP1
PKP2
PKP3
PKP4
PRKACA
PRKCE
PTEN
RNF10
TTC3
UCHL5
USP7
VIM
WEE2-AS1
Entrez ID
839
1832
HPRD ID
03321
00513
Ensembl ID
ENSG00000138794
ENSG00000096696
Uniprot IDs
P55212
A0AAQ5BH43
B4DKX6
P15924
PDB IDs
2WDP
3K7E
3NKF
3NR2
3OD5
3P45
3P4U
3QNW
3S70
3S8E
3V6L
3V6M
4EJF
4FXO
4HVA
4IYR
4N5D
4N6G
4N7J
4N7M
4NBK
4NBL
4NBN
6DEU
6DEV
8EG5
8EG6
8F78
8F96
8F97
8F98
8F99
8F9A
8F9B
8F9C
8F9D
8FBV
1LM5
1LM7
3R6N
5DZZ
Enriched GO Terms of Interacting Partners
?
Regulation Of Programmed Cell Death
Cytoplasm
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Protein Metabolic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Nucleus
Ripoptosome
CD95 Death-inducing Signaling Complex
Response To Stress
Programmed Cell Death
Cell Death
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Death-inducing Signaling Complex
Cytoskeleton Organization
Ubiquitin Protein Ligase Binding
Nuclear Matrix
Negative Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Protein Modification Process
Regulation Of Metabolic Process
Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Cytosol
Regulation Of Protein Metabolic Process
Intermediate Filament
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Neuron Apoptotic Process
Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cellular Response To Stress
Organelle Organization
Structural Constituent Of Cytoskeleton
Structural Constituent Of Nuclear Lamina
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Ubiquitin Ligase Complex
Ubiquitin-ubiquitin Ligase Activity
Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Cell Communication
Response To Hypoxia
Regulation Of Macroautophagy
Positive Regulation Of DNA-binding Transcription Factor Activity
Apolipoprotein Binding
Death Receptor Binding
Astrocyte Activation
Cornified Envelope
Desmosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament
Cysteine-type Endopeptidase Activity
Cell-cell Junction Organization
Desmosome Organization
Cell Junction Assembly
Intermediate Filament Organization
Cysteine-type Peptidase Activity
Cell-cell Junction
Anchoring Junction
Desmosome Assembly
Cell Junction Organization
Positive Regulation Of Neuron Apoptotic Process
Cell-cell Junction Assembly
Cytoplasm
Peptidase Activity
Keratinization
Alpha-catenin Binding
Adherens Junction
Intermediate Filament Cytoskeleton
Cadherin Binding
Desmosome Maintenance
Cytoskeleton Organization
Cytosol
Peptide Cross-linking
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Cell-cell Adhesion
Cell Adhesion
Epidermis Development
Cellular Component Assembly
Positive Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Execution Phase Of Apoptosis
Proteolysis
Cellular Response To Staurosporine
Protein Metabolic Process
Protein Processing
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Protein Maturation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Periphery
Response To Indole-3-methanol
Cell Junction
Structural Constituent Of Cytoskeleton
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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