CASP6 and NUAK1

Number of citations: 0 (PubMedID 15273717)
Data Source: HPRD (in vitro)

		CASP6	NUAK1
Name		caspase 6	NUAK family kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Activation Of Innate Immune Response Proteolysis Apoptotic Process Protein Autoprocessing Epithelial Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Protein Maturation Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Staurosporine Positive Regulation Of Release Of Cytochrome C From Mitochondria Hepatocyte Apoptotic Process	Protein Phosphorylation DNA Damage Response Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Regulation of TP53 Activity through Phosphorylation
Drugs		None	Fostamatinib
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258 )	Alzheimer's disease biomarkers ( 23419831 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) Brain morphology (MOSTest) ( 32665545 ) General glucose level in pregnancy (gestational week 30-32) ( 30324795 ) Lateral ventricular volume in normal aging ( 30258056 ) Medial thalamic nuclei volume ( 34006833 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795 )
Interacting Genes		43 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 RNF31 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC
Entrez ID		839	9891
HPRD ID		03321	12171
Ensembl ID		ENSG00000138794	ENSG00000074590
Uniprot IDs		P55212	O60285
PDB IDs		2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV 8EG5 8EG6 8F78 8F96 8F97 8F98 8F99 8F9A 8F9B 8F9C 8F9D 8FBV	Not available
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Cytoplasm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleus Ripoptosome CD95 Death-inducing Signaling Complex Response To Stress Programmed Cell Death Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Death-inducing Signaling Complex Cytoskeleton Organization Ubiquitin Protein Ligase Binding Nuclear Matrix Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Modification Process Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Cytosol Regulation Of Protein Metabolic Process Intermediate Filament Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Macromolecule Metabolic Process Cellular Response To Stress Organelle Organization Structural Constituent Of Cytoskeleton Structural Constituent Of Nuclear Lamina Positive Regulation Of Metabolic Process Regulation Of Signaling Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Communication Response To Hypoxia Regulation Of Macroautophagy Positive Regulation Of DNA-binding Transcription Factor Activity Apolipoprotein Binding Death Receptor Binding Astrocyte Activation	Protein Metabolic Process Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Postsynapse Macromolecule Metabolic Process Nuclear Chromosome Segregation Sister Chromatid Segregation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Component Organization PTB Domain Binding Regulation Of Synapse Assembly Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Staurosporine Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Microtubule Organizing Center Chromosome Segregation Inner Cell Mass Cell Fate Commitment