CASP6 and UBE4A

Number of citations of the paper that reports this interaction (PMID 11802788)
6

Data Source:
BioGRID (enzymatic study)

		CASP6	UBE4A
Gene Name		caspase 6, apoptosis-related cysteine peptidase	ubiquitination factor E4A
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	11 interactors: CASP6 EPHA2 GZMB MAVS PTTG1 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		839	9354
HPRD ID		03321	06793
Ensembl ID		ENSG00000138794	ENSG00000110344
Uniprot IDs		P55212	Q14139
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA	1WGM
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance	Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Macromolecule Catabolic Process Cellular Response To Stress Apoptotic Process Immune Response-regulating Signaling Pathway Protein K11-linked Ubiquitination Programmed Cell Death Cell Death Death Protein Metabolic Process Positive Regulation Of Immune Response Immune Response Immune System Process Negative Regulation Of Type I Interferon Production Response To Stress Response To Hypoxia Innate Immune Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Positive Regulation Of IP-10 Production Notochord Cell Development Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination
Tagcloud ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Difference) ?		5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Intersection) ?