MOAP1 and THOC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		MOAP1	THOC1
Description		modulator of apoptosis 1	THO complex subunit 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Autophagy Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Autophagosome Assembly	MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA Transport
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Body mass index ( 26426971) Endometriosis ( 23472165) Migraine ( 27182965)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		28 interacting genes: BAX BCL2 BCL2L1 CACNA1A CAMK2D CCDC85B DPPA2 FXR1 FZR1 HUNK LATS1 LCOR MAGEH1 MBIP MEOX2 PNMA5 PPP2R3C RASSF1 RUSC1 SQSTM1 THOC1 TNFRSF10A TNFRSF1A TRIM68 UBQLN2 UBQLN4 UBR5 ZMYND12	32 interacting genes: AGR2 AKAP9 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		64112	9984
HPRD ID		17580	09498
Ensembl ID		ENSG00000165943	ENSG00000079134
Uniprot IDs		Q96BY2	Q96FV9
PDB IDs		7LGC	1WXP 7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death BH3 Domain Binding Nucleus Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Identical Protein Binding Apoptotic Process Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Utilization Release Of Cytochrome C From Mitochondria Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Programmed Cell Death Cell Death B Cell Homeostasis Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand DNA Damage Response Channel Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis Cytoplasm Intracellular Membraneless Organelle Epithelial Cell Apoptotic Process Intracellular Signal Transduction Ovarian Follicle Development Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Developmental Pigmentation Molecular Condensate Scaffold Activity Regulation Of Membrane Depolarization Protein Polyubiquitination Response To Gamma Radiation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrial Membrane Permeability Cellular Response To Stress Lymphocyte Homeostasis Regulation Of Cellular Localization Apoptotic Mitochondrial Changes Apoptotic Signaling Pathway B Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Calcium Ion Transport Into Cytosol Regulation Of Membrane Permeability Regulation Of Developmental Pigmentation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Spliceosomal Complex RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing Cyclin/CDK Positive Transcription Elongation Factor Complex U2-type Precatalytic Spliceosome
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