MOAP1 and THOC1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MOAP1	THOC1
Gene Name		modulator of apoptosis 1	THO complex 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint
Pathways
Drugs
Diseases
GWAS		Endometriosis ( 23472165)	Bipolar disorder and major depressive disorder (combined) ( 20351715)
Protein-Protein Interactions		18 interactors: BAX BCL2 BCL2L1 CACNA1A CAMK2D CCDC85B DPPA2 FZR1 LATS1 MAGEH1 MBIP PNMA5 RASSF1 THOC1 TNFRSF10A TNFRSF1A UBC UBQLN4	13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77
Entrez ID		64112	9984
HPRD ID		17580	09498
Ensembl ID		ENSG00000165943	ENSG00000079134
Uniprot IDs		Q96BY2	Q96FV9
PDB IDs			1WXP
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Extrinsic Apoptotic Signaling Pathway Cell Death Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Process Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Neuron Apoptotic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Process Release Of Cytochrome C From Mitochondria Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Nitrogen Utilization Regulation Of Neuron Death Regulation Of Mitochondrial Membrane Potential Regulation Of Phosphorylation Regulation Of Mitochondrial Membrane Permeability Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Membrane Permeability Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Regulation Of Protein Phosphorylation Regulation Of Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Abiotic Stimulus Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport
Tagcloud ?		adopted alignment atp6 classical cndp2 constructed csde1 csfv dnaja1 dnaja4 fancl fever gaining gopc hemorrhage hnrnph1 indications interactive library ncbi ns2 pnma1 regarded suvec swine switching tmed4 umbilical y2h	biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Difference) ?		adopted alignment atp6 classical cndp2 constructed csde1 csfv dnaja1 dnaja4 fancl fever gaining gopc hemorrhage hnrnph1 indications interactive library ncbi ns2 pnma1 regarded suvec swine switching tmed4 umbilical y2h	biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Intersection) ?