RIPK3 and RFX6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RIPK3	RFX6
Gene Name		receptor-interacting serine-threonine kinase 3	regulatory factor X, 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Ripoptosome	Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Protein Complex Binding Identical Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling T Cell Homeostasis Innate Immune Response Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Heterooligomerization Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Positive Regulation Of Protein Deacetylation Apoptotic Signaling Pathway Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways		IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 20676098)
Protein-Protein Interactions		8 interactors: BIRC2 BIRC3 RFX6 RIPK1 TICAM1 TNFRSF1A TRAF2 XIAP	25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C
Entrez ID		11035	222546
HPRD ID		09315	11490
Ensembl ID		ENSG00000129465	ENSG00000185002
Uniprot IDs		Q9Y572	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Protein Heterooligomerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Programmed Necrotic Cell Death Necrotic Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Innate Immune Response Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Endopeptidase Activity Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Necroptotic Process Regulation Of Peptidase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Intracellular Signal Transduction Protein Oligomerization Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Death Intracellular Signal Transduction Immune Response-regulating Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Tagcloud ?		allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk1 stress stressors switch tnfr1 unresolved	779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Difference) ?		allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk1 stress stressors switch tnfr1 unresolved	779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Intersection) ?