RIPK3 and TICAM1

Number of citations of the paper that reports this interaction (PubMedID 15064760)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RIPK3	TICAM1
Description		receptor interacting serine/threonine kinase 3	TIR domain containing adaptor molecule 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Mitochondrion Endosome Early Endosome Autophagosome Cytosol Endosome Membrane Cytoplasmic Vesicle Ripoptosome
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Gene Expression Programmed Cell Death Activation Of Protein Kinase Activity Regulation Of Type II Interferon Production T Cell Differentiation In Thymus Protein Modification Process Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway B Cell Proliferation B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of B Cell Activation Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death SARS-CoV-1 activates/modulates innate immune responses	Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)	Basal cell carcinoma ( 33549134) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 22561518 27723757)
Interacting Genes		24 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 TRAF6 TRIM25 UTP11 XIAP ZSCAN20	25 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1 WWP2
Entrez ID		11035	148022
HPRD ID		09315	06350
Ensembl ID		ENSG00000129465	ENSG00000127666
Uniprot IDs		Q9Y572	Q8IUC6
PDB IDs		5V7Z 5ZCK 7DA4 7DAC 7MON 7MX3	2M1X 2M63 3RC4 4BSX 4C0M 5JEL 9DK8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Protein Modification Process Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Receptor Complex Ubiquitin Protein Ligase Activity Regulation Of Defense Response Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Defense Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Protein K63-linked Ubiquitination Signaling Adaptor Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Ripoptosome	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Signaling Adaptor Activity Defense Response To Virus Defense Response Positive Regulation Of Innate Immune Response Activation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Defense Response Regulation Of Interferon-beta Production Regulation Of Cell Communication Regulation Of Signaling Immune Response-activating Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Signal Transduction Response To Virus Response To Stress Response To Other Organism Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Type I Interferon-mediated Signaling Pathway Innate Immune Response Regulation Of Defense Response Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Defense Response To Symbiont Interferon-mediated Signaling Pathway Identical Protein Binding
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