RIPK3 and H1-5

Number of citations of the paper that reports this interaction (PubMedID 29883609)
0

Data Source:
BioGRID (pull down)

		RIPK3	H1-5
Description		receptor interacting serine/threonine kinase 3	H1.5 linker histone, cluster member
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Gene Expression Programmed Cell Death Activation Of Protein Kinase Activity Regulation Of Type II Interferon Production T Cell Differentiation In Thymus Protein Modification Process Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Muscle Organ Development Chromosome Condensation Negative Regulation Of DNA Recombination Protein Stabilization Establishment Of Protein Localization To Chromatin
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death SARS-CoV-1 activates/modulates innate immune responses	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		24 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 TRAF6 TRIM25 UTP11 XIAP ZSCAN20	32 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B CEBPA EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		11035	3009
HPRD ID		09315	00821
Ensembl ID		ENSG00000129465	ENSG00000184357
Uniprot IDs		Q9Y572	P16401
PDB IDs		5V7Z 5ZCK 7DA4 7DAC 7MON 7MX3	2RHI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Protein Modification Process Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Receptor Complex Ubiquitin Protein Ligase Activity Regulation Of Defense Response Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Defense Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Protein K63-linked Ubiquitination Signaling Adaptor Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Ripoptosome	Chromatin Remodeling Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Serine Kinase Activity Chromatin Binding Protein Serine/threonine Kinase Activity Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Nucleoplasm Regulation Of DNA Metabolic Process Protein Kinase Activity Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Cellular Response To Stress Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Macromolecule Biosynthetic Process Response To Stress Nucleus Protein Kinase Binding Cyclin A2-CDK2 Complex Negative Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of DNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Cell Cycle G2/M Phase Transition
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