RIPK3 and HELQ

Number of citations of the paper that reports this interaction (PubMedID 29883609)
0

Data Source:
BioGRID (pull down)

		RIPK3	HELQ
Description		receptor interacting serine/threonine kinase 3	helicase, POLQ like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleus Chromosome Site Of DNA Damage
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity	Nucleotide Binding Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Gene Expression Programmed Cell Death Activation Of Protein Kinase Activity Regulation Of Type II Interferon Production T Cell Differentiation In Thymus Protein Modification Process Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Double-strand Break Repair Via Synthesis-dependent Strand Annealing Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)	Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Breast cancer ( 29059683) Menopause (age at onset) ( 22267201 26414677 29773799)
Interacting Genes		24 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 TRAF6 TRIM25 UTP11 XIAP ZSCAN20	1 interacting genes: RIPK3
Entrez ID		11035	113510
HPRD ID		09315	08422
Ensembl ID		ENSG00000129465	ENSG00000163312
Uniprot IDs		Q9Y572	E3W980 Q8TDG4
PDB IDs		5V7Z 5ZCK 7DA4 7DAC 7MON 7MX3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Necroptotic Process Regulation Of Protein Modification Process Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Programmed Necrotic Cell Death Programmed Cell Death Cell Death CD40 Receptor Complex Ubiquitin Protein Ligase Activity Regulation Of Defense Response Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Defense Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Protein K63-linked Ubiquitination Signaling Adaptor Activity Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Transferase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Ripoptosome	Execution Phase Of Necroptosis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of Necroptotic Process Necroptotic Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Necroptotic Process Lymph Node Development Programmed Necrotic Cell Death Spleen Development Regulation Of Activated T Cell Proliferation T Cell Homeostasis Regulation Of T Cell Mediated Cytotoxicity Activation Of Protein Kinase Activity Regulation Of Necroptotic Process Regulation Of Cellular Extravasation Amyloid Fibril Formation T Cell Differentiation In Thymus Non-canonical NF-kappaB Signal Transduction Regulation Of Programmed Necrotic Cell Death Regulation Of T Cell Apoptotic Process Regulation Of T Cell Migration Thymus Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Lymphocyte Migration Lymphocyte Homeostasis Regulation Of Lymphocyte Apoptotic Process Cellular Response To Hydrogen Peroxide Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Homeostasis Hematopoietic Or Lymphoid Organ Development Reactive Oxygen Species Metabolic Process Regulation Of Leukocyte Mediated Cytotoxicity Response To Hydrogen Peroxide Regulation Of T Cell Mediated Immunity Cellular Response To Reactive Oxygen Species Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Type II Interferon Production Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mononuclear Cell Migration T Cell Differentiation Response To Reactive Oxygen Species Regulation Of DNA-binding Transcription Factor Activity Regulation Of T Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway Homeostasis Of Number Of Cells
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?