F13A1 and SERPINF2

Number of citations: 0 (PubMedID 10958788)
Data Source: HPRD (in vitro)

		F13A1	SERPINF2
Name		coagulation factor XIII A chain	serpin family F member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen Blood Microparticle Transferase Complex	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Blood Coagulation Hemostasis Peptide Cross-linking Blood Coagulation, Fibrin Clot Formation	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	Platelet degranulation Dissolution of Fibrin Clot
Drugs		N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex	Ocriplasmin Copper
Diseases		Factor XIII deficiency	Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) End-stage coagulation ( 23381943 ) Entorhinal cortical volume ( 21116278 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Interleukin-10 levels ( 22205395 ) Night sleep phenotypes ( 27126917 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Calcium levels ( 20705733 24068962 ) Hodgkin's lymphoma ( 34216518 ) Serum albumin levels ( 23022100 29403010 ) Severe insulin-deficient type 2 diabetes ( 34737425 ) Urate levels ( 31578528 )
Novel Interactors		1 novel interactors: DYNLL2	1 novel interactors: MYH10
Interacting Genes		13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 KLHL20 NUDT21 SERPINF2 SH3GL2 TK1 UFD1	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		2162	5345
HPRD ID		00604	02029
Ensembl ID		ENSG00000124491	ENSG00000167711
Uniprot IDs		P00488	P08697
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO 8CMT 8CMU	Not available
GO Terms Enriched among Interactors		Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Fibrinolysis Protein Activation Cascade Blood Microparticle Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Gene Expression Blood Coagulation Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Wound Healing Acute-phase Response Regulation Of Response To Wounding Acute Inflammatory Response Platelet Activation Plasminogen Activation Negative Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Cell-matrix Adhesion Regulation Of Fibrinolysis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Protein Maturation Platelet Alpha Granule Circulatory System Process Extracellular Matrix Structural Constituent Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To Calcium Ion Negative Regulation Of Protein Maturation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Coagulation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Signaling Receptor Binding Blood Vessel Diameter Maintenance	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity