F13A1

Name	coagulation factor XIII A chain
Structure
Novel Interactors	1 novel interactors: DYNLL2
Interactors	13 interactors: ANXA7 CDKN1A F13B F2 FGA FGG FN1 KLHL20 NUDT21 SERPINF2 SH3GL2 TK1 UFD1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen Blood Microparticle Transferase Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding
	Biological Process	Blood Coagulation Hemostasis Peptide Cross-linking Blood Coagulation, Fibrin Clot Formation
Pathways	Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling
Drugs	N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex
Diseases	Factor XIII deficiency
GWAS	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) End-stage coagulation ( 23381943 ) Entorhinal cortical volume ( 21116278 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Interleukin-10 levels ( 22205395 ) Night sleep phenotypes ( 27126917 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Entrez ID	2162
HPRD ID	00604
Ensembl ID	ENSG00000124491
Uniprot IDs	P00488
PDB IDs	1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO 8CMT 8CMU
GO Terms Enriched among Interactors ?	Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Fibrinolysis Protein Activation Cascade Blood Microparticle Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Gene Expression Blood Coagulation Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Wound Healing Acute-phase Response Regulation Of Response To Wounding Acute Inflammatory Response Platelet Activation Plasminogen Activation Negative Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Cell-matrix Adhesion Regulation Of Fibrinolysis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Protein Maturation Platelet Alpha Granule Circulatory System Process Extracellular Matrix Structural Constituent Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To Calcium Ion Negative Regulation Of Protein Maturation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Coagulation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Signaling Receptor Binding Blood Vessel Diameter Maintenance