F13A1 and F13B

Number of citations: 0 (PubMedID 8905624)
Data Source: HPRD (in vitro)

		F13A1	F13B
Name		coagulation factor XIII A chain	coagulation factor XIII B chain
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen Blood Microparticle Transferase Complex	Extracellular Region Extracellular Space Transferase Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	None
	Biological Process	Blood Coagulation Hemostasis Peptide Cross-linking Blood Coagulation, Fibrin Clot Formation	Blood Coagulation Hemostasis Blood Coagulation, Fibrin Clot Formation
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	Common Pathway of Fibrin Clot Formation
Drugs		N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex	Zinc Catridecacog Thrombin Human thrombin Zinc acetate
Diseases		Factor XIII deficiency	Factor XIII deficiency
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) End-stage coagulation ( 23381943 ) Entorhinal cortical volume ( 21116278 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Interleukin-10 levels ( 22205395 ) Night sleep phenotypes ( 27126917 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Age-related macular degeneration ( 23536807 ) Erectile dysfunction in type 1 diabetes ( 22704111 ) Lupus nephritis in systemic lupus erythematosus ( 24925725 )
Novel Interactors		1 novel interactors: DYNLL2	1 novel interactors: PTPRC
Interacting Genes		13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 KLHL20 NUDT21 SERPINF2 SH3GL2 TK1 UFD1	2 interacting genes: F13A1 FGG
Entrez ID		2162	2165
HPRD ID		00604	00605
Ensembl ID		ENSG00000124491	ENSG00000143278
Uniprot IDs		P00488	P05160
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO 8CMT 8CMU	8CMT 8CMU
GO Terms Enriched among Interactors		Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Fibrinolysis Protein Activation Cascade Blood Microparticle Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Gene Expression Blood Coagulation Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Wound Healing Acute-phase Response Regulation Of Response To Wounding Acute Inflammatory Response Platelet Activation Plasminogen Activation Negative Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Cell-matrix Adhesion Regulation Of Fibrinolysis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Protein Maturation Platelet Alpha Granule Circulatory System Process Extracellular Matrix Structural Constituent Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To Calcium Ion Negative Regulation Of Protein Maturation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Coagulation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Signaling Receptor Binding Blood Vessel Diameter Maintenance	Blood Coagulation, Fibrin Clot Formation Protein Activation Cascade Platelet Alpha Granule Lumen Coagulation Blood Coagulation Hemostasis Blood Microparticle Plasma Membrane Raft Distribution Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Membrane Microdomain DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Protein Maturation Extracellular Matrix Regulation Of Body Fluid Levels Protein-glutamine Gamma-glutamyltransferase Activity Positive Regulation Of Cell-cell Adhesion Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Plasminogen Activation Fibrinogen Complex External Side Of Plasma Membrane Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Isotype Switching To IgG Isotypes Protein Tyrosine Kinase Inhibitor Activity Positive Regulation Of Gamma-delta T Cell Activation Membrane Raft Distribution Gamma-delta T Cell Differentiation Membrane Raft Localization Bleb Bone Marrow Development Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Gamma-delta T Cell Differentiation Transferase Complex Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative T Cell Selection Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion