F13A1 and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 26687681)
0

Data Source:
BioGRID (two hybrid)

		F13A1	KLHL20
Description		coagulation factor XIII A chain	kelch like family member 20
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen Blood Microparticle Transferase Complex	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Blood Coagulation Hemostasis Peptide Cross-linking Blood Coagulation, Fibrin Clot Formation	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex
Diseases		Factor XIII deficiency
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) End-stage coagulation ( 23381943) Entorhinal cortical volume ( 21116278) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Interleukin-10 levels ( 22205395) Night sleep phenotypes ( 27126917) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Type 2 diabetes (age of onset) ( 28060188) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Feeling miserable ( 29500382)
Interacting Genes		13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 KLHL20 NUDT21 SERPINF2 SH3GL2 TK1 UFD1	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		2162	27252
HPRD ID		00604	13918
Ensembl ID		ENSG00000124491	ENSG00000076321
Uniprot IDs		P00488	Q9Y2M5
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO 8CMT 8CMU	5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Fibrinolysis Protein Activation Cascade Blood Microparticle Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Gene Expression Blood Coagulation Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Wound Healing Acute-phase Response Regulation Of Response To Wounding Acute Inflammatory Response Platelet Activation Plasminogen Activation Negative Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Cell-matrix Adhesion Regulation Of Fibrinolysis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Protein Maturation Platelet Alpha Granule Circulatory System Process Extracellular Matrix Structural Constituent Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To Calcium Ion Negative Regulation Of Protein Maturation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Coagulation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Signaling Receptor Binding Blood Vessel Diameter Maintenance	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I
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