F13A1 and UFD1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		F13A1	UFD1
Name		coagulation factor XIII A chain	ubiquitin recognition factor in ER associated degradation 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Platelet Alpha Granule Lumen Blood Microparticle Transferase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Blood Coagulation Hemostasis Peptide Cross-linking Blood Coagulation, Fibrin Clot Formation	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling	Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex	None
Diseases		Factor XIII deficiency	None
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325 ) End-stage coagulation ( 23381943 ) Entorhinal cortical volume ( 21116278 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Interleukin-10 levels ( 22205395 ) Night sleep phenotypes ( 27126917 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 KLHL20 NUDT21 SERPINF2 SH3GL2 TK1 UFD1	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TMUB1 TP53 UBC VCP
Entrez ID		2162	7353
HPRD ID		00604	06778
Ensembl ID		ENSG00000124491	ENSG00000070010
Uniprot IDs		P00488	Q541A5 Q92890
PDB IDs		1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO 8CMT 8CMU	2YUJ 5B6C 5C1B 7WWQ
GO Terms Enriched among Interactors		Blood Coagulation, Fibrin Clot Formation Fibrinogen Complex Fibrinolysis Protein Activation Cascade Blood Microparticle Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Matrix Negative Regulation Of Gene Expression Blood Coagulation Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Wound Healing Acute-phase Response Regulation Of Response To Wounding Acute Inflammatory Response Platelet Activation Plasminogen Activation Negative Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Cell-matrix Adhesion Regulation Of Fibrinolysis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Protein Maturation Platelet Alpha Granule Circulatory System Process Extracellular Matrix Structural Constituent Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To Calcium Ion Negative Regulation Of Protein Maturation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Blood Coagulation Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Signaling Receptor Binding Blood Vessel Diameter Maintenance	Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Intracellular Signaling Cassette BAT3 Complex Binding ERAD Pathway Intracellular Protein Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Macroautophagy Protein Metabolic Process Growth Cone Proteasomal Protein Catabolic Process Cytosol Macromolecule Catabolic Process Derlin-1 Retrotranslocation Complex Protein Transport VCP-NPL4-UFD1 AAA ATPase Complex Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding Catabolic Process Intracellular Transport Activation Of Membrane Attack Complex Protein Catabolic Process Negative Regulation Of Complement Activation Establishment Of Protein Localization Positive Regulation Of Protein Catabolic Process Regulation Of Immune Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Opsonization Retrograde Protein Transport, ER To Cytosol Macromolecule Metabolic Process Intracellular Protein Localization Ubiquitin-specific Protease Binding Symbiont Cell Surface Intracellular Signal Transduction Regulation Of Fibroblast Apoptotic Process Ubiquitin Binding Negative Regulation Of Autophagy Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small GTPase-mediated Signal Transduction Regulation Of Complement Activation MAP Kinase Kinase Kinase Activity Extracellular Space Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Localization Blood Microparticle