PLCG2 and PRKD1

Number of citations of the paper that reports this interaction (PMID 8885868)
19

Data Source:
HPRD (in vivo)

		PLCG2	PRKD1
Gene Name		phospholipase C, gamma 2 (phosphatidylinositol-specific)	protein kinase D1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Protein Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Blood Coagulation Phospholipid Catabolic Process Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Sphingolipid Metabolic Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Cell Proliferation Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions FCERI mediated MAPK activation Inositol phosphate metabolism DAP12 signaling Toll-Like Receptors Cascades Synthesis of IP3 and IP4 in the cytosol Toll Like Receptor 4 (TLR4) Cascade Role of phospholipids in phagocytosis GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Platelet activation, signaling and aggregation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Body mass index ( 23669352 20935630) Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B	31 interactors: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 GNB2L1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A PLCG1 PLCG2 PPP1R14A PRKCE PRKCH SRC SYK TP53 YWHAQ YWHAZ
Entrez ID		5336	5587
HPRD ID		02570	05668
Ensembl ID		ENSG00000197943	ENSG00000184304
Uniprot IDs		P16885	F8WBA3 Q15139
PDB IDs		2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response Protein Autophosphorylation Immune System Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Defense Response Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Cell Communication B Cell Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification Cell Activation Positive Regulation Of Signal Transduction Response To Stimulus Response To Stress Leukocyte Activation Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Activation Cell Migration Locomotion Phosphorylation Cell Motility Mast Cell Activation Phosphatidylinositol-mediated Signaling Wound Healing Leukocyte Migration Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Fc Receptor Signaling Pathway Cell Activation Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Defense Response Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Blood Coagulation Hemostasis Cell Communication Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organic Substance Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Transport Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Stimulus Response To Growth Factor Programmed Cell Death Wound Healing Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Cellular Response To Organic Substance Cell Death Death Regulation Of Cell Motility Positive Regulation Of Metabolic Process Positive Regulation Of Immune Response Response To Stress
Tagcloud ?		16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?