PLCG2 and LCK

Number of citations of the paper that reports this interaction (PubMedID 7682059)
0

Data Source:
HPRD (in vitro)

		PLCG2	LCK
Description		phospholipase C gamma 2	LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle	Pericentriolar Material Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding ATPase Binding Protein Antigen Binding
	Biological Process	Cell Activation Response To Yeast Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Follicular B Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phospholipid Catabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Programmed Cell Death Lipid Catabolic Process Wnt Signaling Pathway Regulation Of Lipid Metabolic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Negative Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion Cellular Response To Lipid Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lectin	Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Intracellular Zinc Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation CD27 Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Potential therapeutics for SARS Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Co-inhibition by PD-1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOH GTPase cycle Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases
Drugs			Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib Zotiraciclib
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Alzheimer's disease ( 34099642) Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Chronic widespread musculoskeletal pain ( 33331911) Coronary artery disease ( 33020668 29212778) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Takayasu arteritis ( 33308445) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Multiple sclerosis ( 31604244)
Interacting Genes		56 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B	142 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CIMIP2B CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOCS1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70
Entrez ID		5336	3932
HPRD ID		02570	01080
Ensembl ID		ENSG00000197943	ENSG00000182866
Uniprot IDs		P16885	A0A0S2Z3Y8 E9PJ92 E9PKQ8 P06239 Q573B4
PDB IDs		2K2J 2W2W 2W2X 8JQG 8JQH 8JQI 8T7C	1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ 8X2P
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway B Cell Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Activation Of Immune Response Protein Kinase Activity Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphorylation Positive Regulation Of Immune Response Intracellular Signal Transduction Kinase Activity Phosphorylation SH2 Domain Binding Cell Activation Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Raft Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Immune System Process Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway T Cell Activation Cellular Developmental Process Immune Effector Process Leukocyte Proliferation Regulation Of Immune System Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process ATP Binding Positive Regulation Of MAPK Cascade Adaptive Immune Response Protein Autophosphorylation	Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Plasma Membrane Intracellular Signal Transduction T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of Immune Response Leukocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune Response Adaptive Immune Response Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signaling Cassette Regulation Of Cell Activation Protein Kinase Binding Regulation Of T Cell Activation T Cell Activation Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Leukocyte Cell-cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction ERBB Signaling Pathway
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