PLCG2 and EPOR

Number of citations of the paper that reports this interaction (PubMedID 15953601)
0

Data Source:
HPRD (two hybrid, in vivo)

		PLCG2	EPOR
Description		phospholipase C gamma 2	erythropoietin receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Phosphotyrosine Residue Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding Protein Tyrosine Kinase Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Activation Response To Yeast Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Follicular B Cell Differentiation Positive Regulation Of Dendritic Cell Cytokine Production Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phospholipid Catabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Programmed Cell Death Lipid Catabolic Process Wnt Signaling Pathway Regulation Of Lipid Metabolic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Negative Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Calcium Ion Cellular Response To Lipid Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lectin	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Decidualization
Pathways		GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Potential therapeutics for SARS Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Alzheimer's disease ( 34099642) Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Chronic widespread musculoskeletal pain ( 33331911) Coronary artery disease ( 33020668 29212778) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Takayasu arteritis ( 33308445) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		56 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B	42 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 RNF128 RNF43 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL ZNRF3
Entrez ID		5336	2057
HPRD ID		02570	00587
Ensembl ID		ENSG00000197943	ENSG00000187266
Uniprot IDs		P16885	P19235
PDB IDs		2K2J 2W2W 2W2X 8JQG 8JQH 8JQI 8T7C	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6I4X 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL 8VUI 8VVM 8VVO
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway B Cell Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Activation Of Immune Response Protein Kinase Activity Signal Transduction Lymphocyte Activation Leukocyte Activation Protein Phosphorylation Positive Regulation Of Immune Response Intracellular Signal Transduction Kinase Activity Phosphorylation SH2 Domain Binding Cell Activation Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Raft Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Immune System Process Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway T Cell Activation Cellular Developmental Process Immune Effector Process Leukocyte Proliferation Regulation Of Immune System Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process ATP Binding Positive Regulation Of MAPK Cascade Adaptive Immune Response Protein Autophosphorylation	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Immune Effector Process Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Communication Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Activation Erythropoietin-mediated Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Cell Migration B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Motility Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Locomotion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cytosol Positive Regulation Of Mast Cell Proliferation
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