PLCG2 and LAT2

Number of citations of the paper that reports this interaction (PMID 12514734)
40

Data Source:
HPRD (in vitro)

		PLCG2	LAT2
Gene Name		phospholipase C, gamma 2 (phosphatidylinositol-specific)	linker for activation of T cells family, member 2
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Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Mast Cell Granule Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Protein Binding	Protein Binding SH2 Domain Binding
	Biological Process	Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Blood Coagulation Phospholipid Catabolic Process Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol	Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions FCERI mediated MAPK activation Inositol phosphate metabolism DAP12 signaling Toll-Like Receptors Cascades Synthesis of IP3 and IP4 in the cytosol Toll Like Receptor 4 (TLR4) Cascade Role of phospholipids in phagocytosis GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Platelet activation, signaling and aggregation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B	7 interactors: CBL GAB1 GRB2 PLCG1 PLCG2 SOS1 UBQLN4
Entrez ID		5336	7462
HPRD ID		02570	09304
Ensembl ID		ENSG00000197943	ENSG00000086730
Uniprot IDs		P16885	Q9GZY6
PDB IDs		2K2J 2W2W 2W2X	3MAZ
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response Protein Autophosphorylation Immune System Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Defense Response Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Cell Communication B Cell Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification Cell Activation Positive Regulation Of Signal Transduction Response To Stimulus Response To Stress Leukocyte Activation Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Activation Cell Migration Locomotion Phosphorylation Cell Motility Mast Cell Activation Phosphatidylinositol-mediated Signaling Wound Healing Leukocyte Migration Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Defense Response Regulation Of Body Fluid Levels Wound Healing Platelet Activation Cellular Response To Insulin Stimulus Response To Wounding Phospholipid Catabolic Process Leukocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytosis Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Insulin Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Peptide Inositol Phosphate Metabolic Process
Tagcloud ?		16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	adaptor allergic balance cascade collectively degranulation dysregulated effectors fcepsilonri gamma1 grb2 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning
Tagcloud (Difference) ?		16x10 associations chrne comprehensively escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	adaptor allergic balance cascade collectively degranulation effectors fcepsilonri gamma1 grb2 hyper ige ko lat1 linker linking mast negatively orchestrates plc proinflammatory reactions responsiveness signalosome slp tespa1 triggers tuning
Tagcloud (Intersection) ?		dysregulated