PLCG2 and HCK

  • Number of citations of the paper that reports this interaction (PMID 15144186)
  • 48
  • Data Source:
  • HPRD (in vitro)

PLCG2

HCK

Gene Name phospholipase C, gamma 2 (phosphatidylinositol-specific) HCK proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions 34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B 69 interactors: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK C2orf44 CBL CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A GOPC HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 MAP4K5 MTUS2 NOTCH2NL PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TRPV4 TSG101 UNC119 VAV1 WAS WIPF1 WNT2
Entrez ID 5336 3055
HPRD ID 02570 00796
Ensembl ID ENSG00000197943 ENSG00000101336
Uniprot IDs P16885 A8K4G3 P08631
PDB IDs 2K2J 2W2W 2W2X 1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 5HCK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
16x10  associations  chrne  comprehensively  dysregulated  escc  esccs  esophageal  fyn  gc  gcs  germline  gnai3  han  itch  map2k1  map2k4  mapk8  observe  pak4  pik3r3  prlr  rank  resampling  rps6kb2  tln1  validate  warranted  wasl 
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  fyn  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
Tagcloud (Difference) ?
16x10  associations  chrne  comprehensively  dysregulated  escc  esccs  esophageal  gc  gcs  germline  gnai3  han  itch  map2k1  map2k4  mapk8  observe  pak4  pik3r3  prlr  rank  resampling  rps6kb2  tln1  validate  warranted  wasl 
32dcl3  32p  antisera  cbl  eliminated  engagement  fusion  gst  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
Tagcloud (Intersection) ?
fyn